DC-SIGN

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DC-SIGN is a C-type lectin that plays roles in both cell-cell and host-pathogen interactions, and thus serves as a model for both processes. This glycan-binding protein (GBP) paradigm also serves as a model for other members of the C-type lectin family expressed on dendritic cells.


Contents

CFG Participating Investigators contributing to the understanding of this paradigm

Many investigators, both CFG Participating Investigators (PIs) and non-PIs using CFG resources, have led extensive studies on DC-SIGN, particularly regarding structure-function relationships, interactions with pathogens, and signaling functions in dendritic cells.

PIs:

  • Pedro Bonay
  • Angel Corbi
  • Kurt Drickamer
  • Juan Garcia-Vallejo
  • Donald Harn
  • Kayo Inaba
  • Benhur Lee
  • Olivier Neyrolles
  • Irma van Die
  • Yvette van Kooyk
  • William Weis
  • Martin Wild

Non-PIs with who have used CFG resources:

  • Brigitte Gicquel
  • Arne Skerra
  • Ralph Steinman

Progress toward understanding this GBP paradigm

Carbohydrate ligands


Cellular expression


Structure


Biological roles of GBP-ligand interaction


CFG resources used in investigations

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Glycan profiling


Glycogene microarray


Knockout mouse lines

Knockout mice for three potential DC-SIGN orthologues were created by the CFG and distributed to PIs, and their phenotypes were analyzed.


Glycan array

Glycan array analysis and synthetic oligosaccharides were used to elucidate DC-SIGN glycan-binding specificity and analyze the mechanism of specific glycan binding.


CFG database search results for DC-SIGN
Resources Data Molecule Pages
All All All
Reagents Glycan profiling Glycan structures
Mouse lines Glycogene microarray GBP molecules
Resource requests Mouse phenotyping Glycosyltransferases
Other resources Glycan array


Related GBPs

Other dendritic cell lectins include langerin, DCIR, and DCAR. Paralogs on other cells include DC-SIGNR.

References


Acknowledgements

The CFG is grateful to the following PIs for their contributions to this wiki page: Kurt Drickamer, Yvette van Kooyk

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