DC-SIGN is a C-type lectin that plays roles in both cell-cell and host-pathogen interactions, and thus serves as a model for both processes. This glycan-binding protein (GBP) paradigm also serves as a model for other members of the C-type lectin family expressed on dendritic cells.
CFG Participating Investigators contributing to the understanding of this paradigm
Many investigators, both CFG Participating Investigators (PIs) and non-PIs using CFG resources, have led extensive studies on DC-SIGN, particularly regarding structure-function relationships, interactions with pathogens, and signaling functions in dendritic cells.
- Pedro Bonay
- Angel Corbi
- Kurt Drickamer
- Juan Garcia-Vallejo
- Donald Harn
- Kayo Inaba
- Benhur Lee
- Olivier Neyrolles
- Irma van Die
- Yvette van Kooyk
- William Weis
- Martin Wild
Non-PIs with who have used CFG resources:
- Brigitte Gicquel
- Arne Skerra
- Ralph Steinman
Progress toward understanding this GBP paradigm
Biological roles of GBP-ligand interaction
CFG resources used in investigations
Knockout mouse lines
Knockout mice for three potential DC-SIGN orthologues were created by the CFG and distributed to PIs, and their phenotypes were analyzed.
Glycan array analysis and synthetic oligosaccharides were used to elucidate DC-SIGN glycan-binding specificity and analyze the mechanism of specific glycan binding.
|CFG database search results for DC-SIGN|
|Reagents||Glycan profiling||Glycan structures|
|Mouse lines||Glycogene microarray||GBP molecules|
|Resource requests||Mouse phenotyping||Glycosyltransferases|
|Other resources||Glycan array|
Other dendritic cell lectins include langerin, DCIR, and DCAR. Paralogs on other cells include DC-SIGNR.
The CFG is grateful to the following PIs for their contributions to this wiki page: Kurt Drickamer, Yvette van Kooyk