Featured articles
Specially written reviews on the most exiting new findings in glycobiology. For Nature Group Publishing articles, free full access to the publication will be maintained for three months.
November 2006
p53 degradation: N-acetylglucosamine strikes back
Modification of p53 by O-linked N-acetylglucosamine (GlcNAc) at Ser 149 inhibits phosphorylation at Thr 155, thereby preventing ubiquitination and proteosomal degradation.
Original research paper: Nature Cell Biology 8, 1074-1083 (2006)
doi:10.1038/ncb1470Neuronal activity: Polysialic acid as a modulator of neurotransmission
The polysaccharide polysialic acid (PSA) interacts specifically with the NR2B subunit of the N-methyl-D-aspartate-subtype of glutamate receptors (NMDARs) and diminishes glutamate-induced cytotoxicity.
Original research paper: J. Biol. Chem. 281, 34859-34869 (2006)
doi:10.1074/jbc.M602568200