Featured articles
From 2006-2011, the Consortium for Functional Glycomics (CFG) and the Nature Publishing Group (NPG) collaborated to provide the Functional Glycomics Update, a one-stop resource with monthly updates on the latest developments in glycobiology. Here, access the complete archive of Featured Articles, specially written editors' reviews on the most exciting findings in glycobiology. Original pieces created by NPG as part of the NPG-CFG partnership are subject to copyright by the Nature Publishing Group, a division of Macmillan Publishers Limited; used with permission.
November 2006
p53 degradation: N-acetylglucosamine strikes back
Modification of p53 by O-linked N-acetylglucosamine (GlcNAc) at Ser 149 inhibits phosphorylation at Thr 155, thereby preventing ubiquitination and proteosomal degradation.
Original research paper: Nature Cell Biology 8, 1074-1083 (2006)
doi:10.1038/ncb1470Neuronal activity: Polysialic acid as a modulator of neurotransmission
The polysaccharide polysialic acid (PSA) interacts specifically with the NR2B subunit of the N-methyl-D-aspartate-subtype of glutamate receptors (NMDARs) and diminishes glutamate-induced cytotoxicity.
Original research paper: J. Biol. Chem. 281, 34859-34869 (2006)
doi:10.1074/jbc.M602568200
