Research library: browse by date
From 2006-2011, the Consortium for Functional Glycomics (CFG) and the Nature Publishing Group (NPG) collaborated to provide the Functional Glycomics Update, a one-stop resource with monthly updates on the latest developments in glycobiology. This library is a collection of the most significant research advances and key review articles in glycobiology from across the literature, spanning dates from 2006-2011.
August 2007
Immunology: How a T cell sees sugar
D. Branch Moody
Original research paper: Nature (2007)
doi:10.1038/nature05890The Threonine That Carries Fucose, but Not Fucose, Is Required for Cripto to Facilitate Nodal Signaling
S. Shi et al.
Original research paper: Journal of Biological Chemistry 282
doi:10.1074/jbc.M702593200CD1d–lipid-antigen recognition by the semi-invariant NKT T-cell receptor
Natalie A. Borg et al.
Original research paper: Nature (2007)
doi:10.1038/nature05907Differential glycosylation of TH1, TH2 and TH-17 effector cells selectively regulates susceptibility to cell death
Marta A Toscano et al.
Original research paper: Nature Immunology 8 825-834 (2007)
doi:10.1038/ni1482Crystal structure of the extracellular domain of nAChR
1 bound to -bungarotoxin at 1.94 Å resolutionCosma D Dellisanti et al.
Original research paper: Nature Neuroscience 10 953-962 (2007)
doi:10.1038/nn1942Targeting the glycans of glycoproteins: a novel paradigm for antiviral therapy
Jan Balzarini
Original research paper: Nature Reviews Microbiology 5 583-597
doi:10.1038/nrmicro1707α1,3-Galactosyltransferase Gene-Knockout Pigs for Xenotransplantation: Where Do We Go From Here?
David K. C. Cooper et al.
Original research paper: Transplantation 84
doi:10.1097/01.tp.0000260427.75804.f2Gal Knockout Pigs: Any More Carbohydrates?
Mauro S. Sandrin
Original research paper: Transplantation 84
doi:10.1097/01.tp.0000269728.11879.f6Building on the GalKO Platform
Anthony J. F. D'Apice & Peter J. Cowan
Original research paper: Transplantation 84
doi:10.1097/01.tp.0000269740.59820.ceGalT-KO Pigs: Is the Cup Half Empty or Half Full?
David H. Sachs et al.
Original research paper: Transplantation 84
doi:10.1097/01.tp.0000269729.68625.08Chemoenzymatic approaches to glycoprotein synthesis
Clay S. Bennett & Chi-Huey Wong
Original research paper: Chemical Society Reviews 36
doi:10.1039/b617709cMUC1 cell surface mucin is a critical element of the mucosal barrier to infection
Julie L. Mcauley et al.
Original research paper: Journal of Clinical Investigation 117
doi:10.1172/JCI26705The evolution of N-glycan-dependent endoplasmic reticulum quality control factors for glycoprotein folding and degradation
S. Banerjee et al.
Original research paper: Proceedings of the National Academy of Sciences 104
doi:10.1073/pnas.0704862104A ratiometric lectin microarray approach to analysis of the dynamic mammalian glycome
K. T. Pilobello, D. E. Slawek & L. K. Mahal
Original research paper: Proceedings of the National Academy of Sciences 104
doi:10.1073/pnas.0704954104Extracellular structure of polysialic acid explored by on cell solution NMR
H. F. Azurmendi et al.
Original research paper: Proceedings of the National Academy of Sciences 104
doi:10.1073/pnas.0704404104Tumor-derived hyaluronan induces formation of immunosuppressive macrophages through transient early activation of monocytes
D.-M. Kuang et al.
Original research paper: Blood 110
doi:10.1182/blood-2007-01-068031Diverging signaling events control the pathway of GPVI down-regulation in vivo
T. Rabie et al.
Original research paper: Blood 110
doi:10.1182/blood-2006-11-058107Mechanisms of induction of endothelial cell E-selectin expression by smooth muscle cells and its inhibition by shear stress
J.-J. Chiu et al.
Original research paper: Blood 110
doi:10.1182/blood-2006-08-040097C-reactive protein collaborates with plasma lectins to boost immune response against bacteria
Original research paper: The EMBO Journal 26 3431-3440
doi:10.1038/sj.emboj.7601762Chondroitin sulfate glycosaminoglycans control proliferation, radial glia cell differentiation and neurogenesis in neural stem/progenitor cells
S. Sirko et al.
Original research paper: Development 134
doi:10.1242/dev.02871Serine versus Threonine Glycosylation: The Methyl Group Causes a Drastic Alteration on the Carbohydrate Orientation and on the Surrounding Water Shell
F. Corzana et al.
Original research paper: Journal of the American Chemical Society 129
doi:10.1021/ja072181bWeak Calcium-Mediated Interactions between Lewis X-Related Trisaccharides Studied by NMR Measurements of Residual Dipolar Couplings
G. Nodet et al.
Original research paper: Journal of the American Chemical Society 129
doi:10.1021/ja0711056Imaging Cell Surface Glycans with Bioorthogonal Chemical Reporters
P.V. Chang, J.A. Prescher, M.J. Hangauer & C.R. Bertozzi
Original research paper: Journal of the American Chemical Society 129
doi:10.1021/ja070238oPituitary glycoprotein hormone receptors in non-endocrine organs
H Blair, A Wells & C Isales
Original research paper: Trends in Endocrinology & Metabolism 18
doi:10.1016/j.tem.2007.06.001Interpretation support for multistage MS: A mathematical method for theoretical generation of glycan fragments and calculation of their masses
Ningombam Sanjib Meitei & Snigdha Banerjee
Original research paper: PROTEOMICS 7
doi:10.1002/pmic.200600667N-Glycan Structure Annotation of Glycopeptides Using a Linearized Glycan Structure Database (GlyDB)
J.M. Ren, T. Rejtar, L. Li & B.L. Karger
Original research paper: Journal of Proteome Research 6
doi:10.1021/pr070111yAn Enzymatic Deglycosylation Scheme Enabling Identification of Core Fucosylated N-Glycans and O-Glycosylation Site Mapping of Human Plasma Proteins
P. Hagglund et al.
Original research paper: Journal of Proteome Research 6
doi:10.1021/pr0700605Proteomic analysis of N-glycosylation in mosquito dopachrome conversion enzyme
Junsuo S. Li, Christopher J. Vavricka, Bruce M. Christensen & Jianyong Li
Original research paper: PROTEOMICS 7
doi:10.1002/pmic.200601053Functions of Chondroitin Sulfate/Dermatan Sulfate Chains in Brain Development: CRITICAL ROLES OF E AND iE DISACCHARIDE UNITS RECOGNIZED BY A SINGLE CHAIN ANTIBODY GD3G7
A. Purushothaman et al.
Original research paper: Journal of Biological Chemistry 282
doi:10.1074/jbc.M700630200Essential Role of Heparan Sulfate 2-O-Sulfotransferase in Chick Limb Bud Patterning and Development
T. Kobayashi et al.
Original research paper: Journal of Biological Chemistry 282
doi:10.1074/jbc.M610707200Osteopontin Overexpression Inhibits in Vitro Re-endothelialization via Integrin Engagement
D. Leali, E. Moroni, F. Bussolino & M. Presta
Original research paper: Journal of Biological Chemistry 282
doi:10.1074/jbc.M606938200Control of T Cell-mediated Autoimmunity by Metabolite Flux to N-Glycan Biosynthesis
A. Grigorian et al.
Original research paper: Journal of Biological Chemistry 282
doi:10.1074/jbc.M701890200Regulation of Mammalian Protein O-Mannosylation: PREFERENTIAL AMINO ACID SEQUENCE FOR O-MANNOSE MODIFICATION
H. Manya et al.
Original research paper: Journal of Biological Chemistry 282
doi:10.1074/jbc.M702369200Inducible Hyaluronan Production Reveals Differential Effects on Prostate Tumor Cell Growth and Tumor Angiogenesis
A. G. Bharadwaj, K. Rector & M. A. Simpson
Original research paper: Journal of Biological Chemistry 282
doi:10.1074/jbc.M702964200The Extremely Conserved C-terminal Region of Reelin Is Not Necessary for Secretion but Is Required for Efficient Activation of Downstream Signaling
Y. Nakano et al.
Original research paper: Journal of Biological Chemistry 282
doi:10.1074/jbc.M702300200O-Linked Glycosylation at Threonine 27 Protects the Copper Transporter hCTR1 from Proteolytic Cleavage in Mammalian Cells
E. B. Maryon, S. A. Molloy & J. H. Kaplan
Original research paper: Journal of Biological Chemistry 282
doi:10.1074/jbc.M701806200Phosphorylated Galectin-3 Mediates Tumor Necrosis Factor-related Apoptosis-inducing Ligand Signaling by Regulating Phosphatase and Tensin Homologue Deleted on Chromosome 10 in Human Breast Carcinoma Cells
N. Mazurek et al.
Original research paper: Journal of Biological Chemistry 282
doi:10.1074/jbc.M608810200Recognition Mechanism of Galectin-4 for Cholesterol 3-Sulfate
H. Ideo, A. Seko & K. Yamashita
Original research paper: Journal of Biological Chemistry 282
doi:10.1074/jbc.M703770200Inhibition of a Specific N-Glycosylation Activity Results in Attenuation of Breast Carcinoma Cell Invasiveness-related Phenotypes: INHIBITION OF EPIDERMAL GROWTH FACTOR-INDUCED DEPHOSPHORYLATION OF FOCAL ADHESION KINASE
H.-B. Guo, M. Randolph & M. Pierce
Original research paper: Journal of Biological Chemistry 282
doi:10.1074/jbc.M611518200Identification of CLEC12B, an Inhibitory Receptor on Myeloid Cells
S. C. Hoffmann et al.
Original research paper: Journal of Biological Chemistry 282
doi:10.1074/jbc.M704250200Membrane Glycoprotein M6a Interacts with the µ-Opioid Receptor and Facilitates Receptor Endocytosis and Recycling
D.-F. Wu et al.
Original research paper: Journal of Biological Chemistry 282
doi:10.1074/jbc.M700941200Distinct Endocytic Mechanisms of CD22 (Siglec-2) and Siglec-F Reflect Roles in Cell Signaling and Innate Immunity
H. Tateno et al.
Original research paper: Molecular and Cellular Biology 27
doi:10.1128/MCB.00383-07Neisseria gonorrhoeae O-linked pilin glycosylation: functional analyses define both the biosynthetic pathway and glycan structure
Finn Erik Aas et al.
Original research paper: Molecular Microbiology 65
doi:10.1111/j.1365-2958.2007.05806.xTransforming Growth Factor α-Dependent Cancer Progression Is Modulated by Muc1
M. R. Pochampalli, B. G. Bitler & J. A. Schroeder
Original research paper: Cancer Research 67
doi:10.1158/0008-5472.CAN-06-4518Molecular basis for acceptor substrate specificity of the human α1,3-glucuronosyltransferases GlcAT-I and GlcAT-P involved in glycosaminoglycan and HNK-1 carbohydrate epitope biosynthesis, respectively
M. Fondeur-gelinotte et al.
Original research paper: Glycobiology 17
doi:10.1093/glycob/cwm055O-linked glycan expression during Drosophila development
E Tian & K. G T. Hagen
Original research paper: Glycobiology 17
doi:10.1093/glycob/cwm056Anti-asthmatic potential of a D-galactose-binding lectin from Synadenium carinatum latex
A. P Rogerio et al.
Original research paper: Glycobiology 17
doi:10.1093/glycob/cwm053Glycosaminoglycans in Hydra magnipapillata (Hydrozoa, Cnidaria): demonstration of chondroitin in the developing nematocyst, the sting organelle, and structural characterization of glycosaminoglycans
S. Yamada, H. Morimoto, T. Fujisawa & K. Sugahara
Original research paper: Glycobiology 17
doi:10.1093/glycob/cwm051NetCGlyc 1.0: prediction of mammalian C-mannosylation sites
K. Julenius
Original research paper: Glycobiology 17
doi:10.1093/glycob/cwm050High-throughput carbohydrate microarray profiling of 27 antibodies demonstrates widespread specificity problems
J. C Manimala, T. A Roach, Z. Li & J. C Gildersleeve
Original research paper: Glycobiology 17
doi:10.1093/glycob/cwm047Metabolic homeostasis and tissue renewal are dependent on β1,6GlcNAc-branched N-glycans
P. Cheung et al.
Original research paper: Glycobiology 17
doi:10.1093/glycob/cwm048Siglec-15: an immune system Siglec conserved throughout vertebrate evolution
T. Angata, Y. Tabuchi, K. Nakamura & M. Nakamura
Original research paper: Glycobiology 17
doi:10.1093/glycob/cwm049Mgat5 and Pten interact to regulate cell growth and polarity
P. Cheung & J. W. Dennis
Original research paper: Glycobiology 17
doi:10.1093/glycob/cwm037Characterization of the Fucosylation Pathway in the Biosynthesis of Glycopeptidolipids from Mycobacterium avium Complex
Y. Miyamoto et al.
Original research paper: Journal of Bacteriology 189
doi:10.1128/JB.00344-07Lectin-Based Food Poisoning: A New Mechanism of Protein Toxicity
Katsuya Miyake, Toru Tanaka, Paul L. Mcneil & Richard Steinhardt
Original research paper: PLoS ONE 2
doi:10.1371/journal.pone.0000687Glycosylation and annexin II cell surface translocation mediate airway epithelial wound repair
B. J. Patchell et al.
Original research paper: AJP: Lung Cellular and Molecular Physiology 293
doi:10.1152/ajplung.00412.2006Changes in versican and chondroitin sulfate proteoglycans during structural development of the lung
J. Faggian et al.
Original research paper: AJP: Regulatory, Integrative and Comparative Physiology 293
doi:10.1152/ajpregu.00801.2006Epithelial Cell Adhesion Molecule: More than a Carcinoma Marker and Adhesion Molecule
M. Trzpis, P. M.J. Mclaughlin, L. M.F.H. De leij & M. C. Harmsen
Original research paper: American Journal Of Pathology 171
doi:10.2353/ajpath.2007.070152Tags for the Stable Isotopic Labeling of Carbohydrates and Quantitative Analysis by Mass Spectrometry
M.J. Bowman & J. Zaia
Original research paper: Analytical Chemistry 79
doi:10.1021/ac070581bIsolation of N-Linked Glycopeptides from Plasma
Y. Zhou, R. Aebersold & H. Zhang
Original research paper: Analytical Chemistry 79
doi:10.1021/ac0623181Analysis of Cell Surface Carbohydrate Expression Patterns in Normal and Tumorigenic Human Breast Cell Lines Using Lectin Arrays
S. Chen et al.
Original research paper: Analytical Chemistry 79
doi:10.1021/ac070423kMetabolic Cytometry. Glycosphingolipid Metabolism in Single Cells
C.D. Whitmore et al.
Original research paper: Analytical Chemistry 79
doi:10.1021/ac070716dRole of galectin-3 in prion infections of the CNS
S Mok et al.
Original research paper: Biochemical and Biophysical Research Communications 359
doi:10.1016/j.bbrc.2007.05.163Crucial roles of binding sites for NF-κB and C/EBPs in IκB-ζ-mediated transcriptional activation
Susumu Matsuo, Soh Yamazaki, Koichiro Takeshige & Tatsushi Muta
Original research paper: Biochemical Journal 405
doi:10.1042/BJ20061797A Haemophilus influenzae Strain Associated with Fisher Syndrome Expresses a Novel Disialylated Ganglioside Mimic
R.S. Houliston et al.
Original research paper: Biochemistry 46
doi:10.1021/bi700685sProteoglycans: key partners in bone cell biology
François Lamoureux et al.
Original research paper: BioEssays 29
doi:10.1002/bies.20612Lectin-modified microchannels for mammalian cell capture and purification
Ting Zheng et al.
Original research paper: Biomedical Microdevices 9
doi:10.1007/s10544-007-9074-2The C-type lectin MGL expressed by dendritic cells detects glycan changes on MUC1 in colon carcinoma
Eirikur Saeland et al.
Original research paper: Cancer Immunology, Immunotherapy 56
doi:10.1007/s00262-006-0274-zDifferences in tropism and pH dependence for glycoproteins from the Clade B1 arenaviruses: Implications for receptor usage and pathogenicity
J Oldenburg et al.
Original research paper: Virology 364
doi:10.1016/j.virol.2007.03.003Ebola virus-like particle-induced activation of NF-κB and Erk signaling in human dendritic cells requires the glycoprotein mucin domain
O Martinez, C Valmas & C Basler
Original research paper: Virology 364
doi:10.1016/j.virol.2007.03.020An Emerging Role for Galectins in Tuning the Immune Response: Lessons from Experimental Models of Inflammatory Disease, Autoimmunity and Cancer
G. A. Rabinovich, F.-T. Liu, M. Hirashima & A. Anderson
Original research paper: Scandinavian Journal of Immunology 66
doi:10.1111/j.1365-3083.2007.01986.xExpression of oligodendrocyte myelin glycoprotein and its receptor NgR after the injury of rat central nervous system
Q Guo, S Li & B Su
Original research paper: Neuroscience Letters 422
doi:10.1016/j.neulet.2007.05.034Hepatitis C Virus Envelope Glycoprotein E2 Glycans Modulate Entry, CD81 Binding, and Neutralization
E. Falkowska et al.
Original research paper: Journal of Virology 81
doi:10.1128/JVI.00459-07The Neutralizing Activity of Anti-Hepatitis C Virus Antibodies Is Modulated by Specific Glycans on the E2 Envelope Protein
F. Helle et al.
Original research paper: Journal of Virology 81
doi:10.1128/JVI.00127-07Identification of the Optimal DC-SIGN Binding Site on Human Immunodeficiency Virus Type 1 gp120
P. W.-P. Hong et al.
Original research paper: Journal of Virology 81
doi:10.1128/JVI.01765-06Human Parainfluenza Viruses hPIV1 and hPIV3 Bind Oligosaccharides with 2-3-Linked Sialic Acids That Are Distinct from Those Bound by H5 Avian Influenza Virus Hemagglutinin
M. Amonsen, D. F. Smith, R. D. Cummings & G. M. Air
Original research paper: Journal of Virology 81
doi:10.1128/JVI.00718-07N-Linked Glycosylation Attenuates H3N2 Influenza Viruses
D. J. Vigerust et al.
Original research paper: Journal of Virology 81
doi:10.1128/JVI.00769-07Induction of Calcium Influx through TRPC5 Channels by Cross-Linking of GM1 Ganglioside Associated with 5 1 Integrin Initiates Neurite Outgrowth
G. Wu et al.
Original research paper: Journal of Neuroscience 27
doi:10.1523/JNEUROSCI.4266-06.2007Rational proteomics of PKD1. I. Modeling the three dimensional structure and ligand specificity of the C_lectin binding domain of Polycystin-1.
Vladimir Pletnev et al.
Original research paper: Journal of Molecular Modeling 13
doi:10.1007/s00894-007-0201-zKinetics of mobilization and differentiation of lymphohematopoietic cells during experimental murine schistosomiasis in galectin-3 / mice
F. L. Oliveira et al.
Original research paper: Journal of Leukocyte Biology 82
doi:10.1189/jlb.1206747The 130-kDa Glycoform of CD43 Functions as an E-Selectin Ligand for Activated Th1 Cells In Vitro and in Delayed-Type Hypersensitivity Reactions In Vivo
Pilar Alcaide et al.
Original research paper: Journal of Investigative Dermatology 127
doi:10.1038/sj.jid.5700805Contribution of Glycosylation to T Cell Responses Stimulated by Recombinant Mannoprotein
Charles A. Specht et al.
Original research paper: The Journal of Infectious Diseases 196
doi:10.1086/520536Characterization of a novel modification on IgG2 light chain Evidence for the presence of O-linked mannosylation
T. Martinez et al.
Original research paper: Journal of Chromatography A 1156
doi:10.1016/j.chroma.2007.04.050Effects of mannosylated glycopolymers on specific interaction to bone marrow hematopoietic and progenitor cells derived from murine species
Keun-Hong Park et al.
Original research paper: Journal of Biomedical Materials Research Part A 82A
doi:10.1002/jbm.a.31137Lectin from Phaseolus acutifolius var. escumite: Chemical Characterization, Sugar Specificity, and Effect on Human T-Lymphocytes
A. Castillo-villanueva et al.
Original research paper: Journal of Agricultural and Food Chemistry 55
doi:10.1021/jf063644kRole of S128R polymorphism of E-selectin in colon metastasis formation
Riccardo Alessandro et al.
Original research paper: International Journal of Cancer 121
doi:10.1002/ijc.22693Heptose I Glycan Substitutions on Neisseria gonorrhoeae Lipooligosaccharide Influence C4b-Binding Protein Binding and Serum Resistance
S. Ram et al.
Original research paper: Infection and Immunity 75
doi:10.1128/IAI.01109-06Expression of hGC-1 is correlated with differentiation of gastric carcinoma
W Liu, J Zhu, L Cao & G P Rodgers
Original research paper: Histopathology 51
doi:10.1111/j.1365-2559.2007.02763.xPurification and characterisation of a natural lectin from the serum of the shrimp Litopenaeus vannamei
J Sun et al.
Original research paper: Fish & Shellfish Immunology 23
doi:10.1016/j.fsi.2006.11.001Glycoprotein folding and the role of EDEM1, EDEM2 and EDEM3 in degradation of folding-defective glycoproteins
S Olivari & M Molinari
Original research paper: FEBS Letters 581
doi:10.1016/j.febslet.2007.04.070N-glycan structures and associated gene expression reflect the characteristic N-glycosylation pattern of human hematopoietic stem and progenitor cells
H Hemmoranta et al.
Original research paper: Experimental Hematology 35
doi:10.1016/j.exphem.2007.05.006Nanoscale Organization of the Pathogen Receptor DC-SIGN Mapped by Single-Molecule High-Resolution Fluorescence Microscopy
Bärbel I. De bakker et al.
Original research paper: ChemPhysChem 8
doi:10.1002/cphc.2007001691,2-Mannobioside Mimic: Synthesis, DC-SIGN Interaction by NMR and Docking, and Antiviral Activity
José J. Reina et al.
Original research paper: ChemMedChem 2
doi:10.1002/cmdc.200700047
