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Research highlights

Short accessible highlights that put into context must-read papers related to Functional Glycomics

  • December 2007

    • Malaria infection: Heparan sulfate says open sesame

      Proteolytic cleavage of the Plasmodium sporozoite cell surface circumsporozoite protein (CSP) is triggered by hepatocyte highly sulfated heparan sulfate proteoglycans (HSPGs), initiating a signaling pathway that involves calcium-dependent protein kinase (CDPK)-6 and leads to the switch from sporozoite migration to invasion.

      Functional Glycomics Gateway (2007)
      doi:10.1038/fg.2007.52

    • Leukocyte recruitment: Selectin the way forward

      Clathrin-coated pits and lipid raft membrane subdomains sequester E-selectin molecules and regulate the rolling of leukocytes toward sites of inflammation.

      Functional Glycomics Gateway (2007)
      doi:10.1038/fg.2007.53

    • Cell proliferation: Rafting through the lattice

      Cell surface glycan-galectin lattices interact with membrane microdomains and control the presence of molecules involved in signal transduction and endocytosis.

      Functional Glycomics Gateway (2007)
      doi:10.1038/fg.2007.54

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