Research highlights
From 2006-2011, the Consortium for Functional Glycomics (CFG) and the Nature Publishing Group (NPG) collaborated to provide the Functional Glycomics Update, a one-stop resource with monthly updates on the latest developments in glycobiology. Here, access the complete archive of Research Highlights, short accessible pieces that put into context must-read papers related to Functional Glycomics. Original pieces created by NPG as part of the NPG-CFG partnership are subject to copyright by the Nature Publishing Group, a division of Macmillan Publishers Limited; used with permission.
February 2008
T cell and fly development: Sugars boost signaling up a Notch
Two articles have shown that Drosophila development requires Notch O-glucosylation by the transferase Rumi, and that Notch1 O-fucosylation in the ligand binding domain regulates T cell development in mice.
Functional Glycomics Gateway (2008)
doi:10.1038/fg.2008.8Cancer cell signaling: Glypican-1 gathers growth factors
The heparan sulfate carrier glypican-1 promotes mitogenic and angiogenic signaling in pancreatic tumors.
Functional Glycomics Gateway (2008)
doi:10.1038/fg.2008.9Innate immunity: S. aureus surrenders to mannose-binding lectin
Mannose-binding lectin (MBL) binds to Staphylococcus aureus prior to phagocytosis; once engulfed, MBL interacts with Toll-like receptor (TLR) 2 and TLR6 in the phagosome to initiate proinflammatory signaling.
Functional Glycomics Gateway (2008)
doi:10.1038/fg.2008.10Glycopharmacology: Mannoside mania
Synthetic tetra- and hexavalent mannosides block the effects of concanavalin A treatment on membrane type-1 matrix metalloproteinase (MT1-MMP)-mediated signaling in bone marrow-derived mesenchymal stromal cells (MSCs).
Functional Glycomics Gateway (2008)
doi:10.1038/fg.2008.11
