Cell Signaling
Separable requirements for cytoplasmic domain of PSGL-1 in leukocyte rolling and signaling under flow
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Original research paper: The Journal of Cell Biology 182
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doi:10.1016/j.cell.2008.06.006The Ever-Lengthening Arm of p53
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Original research paper: Cancer Cell 14
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Original research paper: Journal of Biological Chemistry 283
doi:10.1074/jbc.M804116200CD44-Epidermal Growth Factor Receptor Interaction Mediates Hyaluronic Acid-promoted Cell Motility by Activating Protein Kinase C Signaling Involving Akt, Rac1, Phox, Reactive Oxygen Species, Focal Adhesion Kinase, and MMP-2
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Original research paper: Journal of Biological Chemistry 283
doi:10.1074/jbc.M708319200Syndecan-4 regulates platelet-derived growth factor-mediated MAP kinase activation by altering intracellular reactive oxygen species
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Original research paper: Journal of Biochemistry 144
doi:10.1093/jb/mvn089MUC1 Oncoprotein Regulates Bcr-Abl Stability and Pathogenesis in Chronic Myelogenous Leukemia Cells
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Original research paper: Journal of Cell Science 120
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Original research paper: Journal of Biological Chemistry 282
doi:10.1074/jbc.M705833200Galactomutarotase and Other Galactose-Related Genes Are Rapidly Induced by Retinoic Acid in Human Myeloid Cells
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Original research paper: Biochemistry 46
doi:10.1021/bi701891tLaminin-Induced Activation of Rac1 and JNKp46 Is Initiated by Src Family Kinases and Mimics the Effects of Skeletal Muscle Contraction
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Original research paper: Biochemistry 46
doi:10.1021/bi701384kStat3 is involved in control of MASP2 gene expression
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Original research paper: Biochemical and Biophysical Research Communications
doi:10.1016/j.bbrc.2007.10.114Rumi Is a CAP10 Domain Glycosyltransferase that Modifies Notch and Is Required for Notch Signaling
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Original research paper: Proceedings of the National Academy of Sciences 105
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Original research paper: The Journal of Cell Biology 179
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Original research paper: Cell Death and Differentiation 15 408-419 (2007)
doi:10.1038/sj.cdd.4402278The Differential Impact of Disulfide Bonds and N-Linked Glycosylation on the Stability and Function of CD14
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Original research paper: Journal of Biological Chemistry 283
doi:10.1074/jbc.M707640200Enzyme-dependent Variations in the Polysialylation of the Neural Cell Adhesion Molecule (NCAM) in Vivo
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Original research paper: Journal of Biological Chemistry 283
doi:10.1074/jbc.M707024200Tetra- and hexavalent mannosides inhibit the pro-apoptotic, antiproliferative and cell surface clustering effects of concanavalin-A: Impact on MT1-MMP functions in marrow-derived mesenchymal stromal cells
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Original research paper: Glycobiology 18
doi:10.1093/glycob/cwm133Role of glycosaminoglycans for binding and infection of hepatitis B virus
Corinna M. Leistner, Stefanie Gruen-bernhard & Dieter Glebe
Original research paper: Cellular Microbiology 0
doi:10.1111/j.1462-5822.2007.01023.xChondroitin sulfate and heparan sulfate-containing proteoglycans are both partners and targets of basic fibroblast growth factor-mediated proliferation in human metastatic melanoma cell lines
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Original research paper: The International Journal of Biochemistry & Cell Biology 40
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Original research paper: Journal of Leukocyte Biology 83
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Original research paper: Journal of Leukocyte Biology 83
doi:10.1189/jlb.0607388An exposed carboxyl group on sialic acid is essential for gangliosides to inhibit calcium uptake via the sarco/endoplasmic reticulum Ca -ATPase: relevance to gangliosidoses
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Original research paper: Journal of Neurochemistry 0
doi:10.1111/j.1471-4159.2007.04983.xN-acetylglucosaminyltransferase V mediates cell migration and invasion of mouse mammary tumor cells 4TO7 via RhoA and Rac1 signaling pathway
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Original research paper: Molecular and Cellular Biochemistry 309
doi:10.1007/s11010-007-9656-6Lectins sweet-talk proteins into ERAD
How cells decide that a protein is misfolded is a mystery. The endoplasmic reticulum integrates N-linked glycosylation into the decision as to whether a protein is misfolded. The basic strategy of glycan-based recognition, previously identified in yeast, is conserved in mammals but is expanded, possibly to accommodate a more complex client portfolio.
Songyu Wang & Davis T. W. Ng
Original research paper: Nature Cell Biology 10 251-253
doi:10.1038/ncb0308-251OS-9 and GRP94 deliver mutant
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Original research paper: Nature Cell Biology 10 272-282 (2008)
doi:10.1038/ncb1689Ganglioside GM2/GM3 complex affixed on silica nanospheres strongly inhibits cell motility through CD82/cMet-mediated pathway
A. R. Todeschini, J. N. Dos santos, K. Handa & S.-i. Hakomori
Original research paper: Proceedings of the National Academy of Sciences 105
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Original research paper: The Journal of Cell Biology 180
doi:10.1083/jcb.200709100Glucose Deprivation Stimulates O-GlcNAc Modification of Proteins through Up-regulation of O-Linked N-Acetylglucosaminyltransferase
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Original research paper: Journal of Biological Chemistry 283
doi:10.1074/jbc.M707328200Hyaluronan-CD44-ERK1/2 Regulate Human Aortic Smooth Muscle Cell Motility during Aging
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Original research paper: Journal of Biological Chemistry 283
doi:10.1074/jbc.M709051200GM1-induced activation of phosphatidylinositol 3-kinase: involvement of Trk receptors
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Original research paper: Journal of Neurochemistry 104
doi:10.1111/j.1471-4159.2007.05088.xHyaluronan oligosaccharides sensitize lymphoma resistant cell lines to vincristine by modulating P-glycoprotein activity and PI3K/Akt pathway
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Original research paper: International Journal of Cancer 122
doi:10.1002/ijc.23122Antisense glutaminase inhibition modifies the O-GlcNAc pattern and flux through the hexosamine pathway in breast cancer cells
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Original research paper: Journal of Cellular Biochemistry 103
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Original research paper: FEBS Letters 582
doi:10.1016/j.febslet.2008.02.010Glycoprotein targeting signals influence the distribution of measles virus envelope proteins and virus spread in lymphocytes
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doi:10.1126/science.1151363Concerted regulation of focal adhesion dynamics by galectin-3 and tyrosine-phosphorylated caveolin-1
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Original research paper: The Journal of Cell Biology
doi:10.1083/jcb.200709019MCF7 Side Population Cells with Characteristics of Cancer Stem/Progenitor Cells Express the Tumor Antigen MUC1
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Original research paper: The FASEB Journal 22
doi:10.1096/fj.07-9524comCD40 Ligand Promotes Mac-1 Expression, Leukocyte Recruitment, and Neointima Formation after Vascular Injury
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Original research paper: American Journal Of Pathology 172
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Original research paper: Journal of Biological Chemistry 283
doi:10.1074/jbc.C700221200Smad and p38 MAP Kinase-mediated Signaling of Proteoglycan Synthesis in Vascular Smooth Muscle
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Original research paper: Journal of Biological Chemistry 283
doi:10.1074/jbc.M703125200Hyaluronan Facilitates Transforming Growth Factor- 1-mediated Fibroblast Proliferation
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doi:10.1074/jbc.M704819200Structural insight into Slit–Robo signalling
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Original research paper: Biochemical Society Transactions 36
doi:10.1042/BST0360251Transcriptional regulation of the fucosyltransferase VI gene in hepatocellular carcinoma cells
Koji Higai, Noriko Miyazaki, Yutaro Azuma & Kojiro Matsumoto
Original research paper: Glycoconjugate Journal 25
doi:10.1007/s10719-008-9114-zSialic acid metabolism is involved in the regulation of gene expression during neuronal differentiation of PC12 cells
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Original research paper: Glycoconjugate Journal 25
doi:10.1007/s10719-008-9104-1Protein Modification by O-Linked GlcNAc Reduces Angiogenesis by Inhibiting Akt Activity in Endothelial Cells
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Original research paper: Arteriosclerosis, Thrombosis, and Vascular Biology 28
doi:10.1161/ATVBAHA.107.159533Defining the Regulated Secreted Proteome of Rodent Adipocytes upon the Induction of Insulin Resistance
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doi:10.1016/j.molimm.2007.11.006Natural and recombinant human glycodelin activate a proapoptotic gene cascade in monocyte cells
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Original research paper: Nature Immunology 9 513-521 (2008)
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doi:10.1101/gad.1669308Regulation of TGF- signalling by N-acetylgalactosaminyltransferase-like 1
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doi:10.1128/IAI.01528-07Chondroitin sulfate prevents platelet derived growth factor-mediated phosphorylation of PDGF-Rβ in normal human fibroblasts severely impairing mitogenic responses
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Original research paper: Journal of Cellular Biochemistry 103
doi:10.1002/jcb.21570Protein-glycan interactions in the control of innate and adaptive immune responses
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doi:10.1038/ni.f.203Inhibition of N-Linked Glycosylation Disrupts Receptor Tyrosine Kinase Signaling in Tumor Cells
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doi:10.1242/dev.020461The Hyaluronan Receptor for Endocytosis Mediates Hyaluronan-dependent Signal Transduction via Extracellular Signal-regulated Kinases
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doi:10.1074/jbc.M709921200Roles of Pofut1 and O-Fucose in Mammalian Notch Signaling
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Original research paper: Journal of Biological Chemistry 283
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Original research paper: Journal of Biological Chemistry 283
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Original research paper: Journal of Biological Chemistry 283
doi:10.1074/jbc.M709575200Calsenilin and CALP interact with the cytoplasmic tail of UDP-Gal:GA2/GM2/GD2 β-1,3-galactosyltransferase
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Original research paper: Journal of Neuroscience Research 86
doi:10.1002/jnr.21603Thematic Review Series: Sphingolipids. Nuclear sphingolipids: metabolism and signaling
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Original research paper: The Journal of Lipid Research 49
doi:10.1194/jlr.R800009-JLR200Opposing roles for glypicans in Hedgehog signalling
Glypican members of the heparan sulphate proteoglycan family regulate several developmental signalling pathways, such as those involving Hedgehog, Wnt, BMP and FGF. Two studies reveal opposite effects of glypicans on Hedgehog signalling and show how their core protein domains and GPI anchor contribute to their versatile biological functions.
Dong Yan & Xinhua Lin
Original research paper: Nature Cell Biology 10 761-763
doi:10.1038/ncb0708-761Glypican-3 Inhibits Hedgehog Signaling during Development by Competing with Patched for Hedgehog Binding
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Original research paper: The Journal of Cell Biology 181
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Original research paper: Oncogene 27 3746-3753 (2008)
doi:10.1038/sj.onc.1211029Glypican-1 Regulates Anaphase Promoting Complex/Cyclosome Substrates and Cell Cycle Progression in Endothelial Cells
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Original research paper: Molecular Biology of the Cell 19
doi:10.1091/mbc.E07-10-1025Hyaluronan-CD44 Interaction Activates Stem Cell Marker Nanog, Stat-3-mediated MDR1 Gene Expression, and Ankyrin-regulated Multidrug Efflux in Breast and Ovarian Tumor Cells
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Original research paper: Journal of Biological Chemistry 283
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Original research paper: Biochemical and Biophysical Research Communications 371
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Original research paper: Journal of Cellular Biochemistry 104
doi:10.1002/jcb.21715Cell-surface nucleolin is a signal transducing P-selectin binding protein for human colon carcinoma cells
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Original research paper: Experimental Cell Research 314
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doi:10.1126/science.1159411Removal of sialic acid involving Klotho causes cell-surface retention of TRPV5 channel via binding to galectin-1
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doi:10.1016/j.semcancer.2008.03.007Regulation of the O-Linked -N-Acetylglucosamine Transferase by Insulin Signaling
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Original research paper: Journal of Biological Chemistry 283
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Original research paper: Journal of Biological Chemistry 283
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Original research paper: Journal of Biological Chemistry 283
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