Clinical/Drug Discovery

• A facile synthesis of 1,6-dideoxynojirimycin from l-sorbose

  J An, X Meng, Y Yao & Z Li
  Original research paper: Carbohydrate Research 341
  doi:10.1016/j.carres.2006.06.002

  Abstract

• Physicochemical properties and antitumor activities of water-soluble native and sulfated hyperbranched mushroom polysaccharides

  Y Tao, L Zhang & P Cheung
  Original research paper: Carbohydrate Research 341
  doi:10.1016/j.carres.2006.05.024

  Abstract

• Clearance mechanism of a mannosylated antibody-enzyme fusion protein used in experimental cancer therapy

  H. Kogelberg et al.
  Original research paper: Glycobiology 17
  doi:10.1093/glycob/cwl053

  Abstract

• Cyanovirin-N Inhibits Hepatitis C Virus Entry by Binding to Envelope Protein Glycans

  F. Helle
  Original research paper: Journal of Biological Chemistry 281
  doi:10.1074/jbc.M602431200

  Abstract

• A sugar switch for anti-inflammatory antibodies

  The finding that antibody sialylation can suppress inflammation provides new opportunities for drug development.

  Roy Jefferis
  Original research paper: Nature Biotechnology 24 1230-1231
  doi:10.1038/nbt1006-1230

  Abstract

• Sulfated L-selectin ligands as a therapeutic target in chronic inflammation

  K Uchimura & S Rosen
  Original research paper: Trends in Immunology 27
  doi:10.1016/j.it.2006.10.007

  Abstract

• A male contraceptive targeting germ cell adhesion

  Dolores D Mruk, Ching-Hang Wong, Bruno Silvestrini & C Yan Cheng
  Original research paper: Nature Medicine 12 1323-1328 (2006)
  doi:10.1038/nm1420

  Abstract

• UDP-Gal: GlcNAc-R β1,4-galactosyltransferase—a target enzyme for drug design. Acceptor specificity and inhibition of the enzyme

  Inka Brockhausen et al.
  Original research paper: Glycoconjugate Journal 23
  doi:10.1007/s10719-006-7153-x

  Abstract

• GlycoPEGylation of recombinant therapeutic proteins produced in Escherichia coli

  S. Defrees
  Original research paper: Glycobiology 16
  doi:10.1093/glycob/cwl004

  Abstract

• Insights in the glycosylation steps during biosynthesis of the antitumor anthracycline cosmomycin: characterization of two glycosyltransferase genes

  Leandro M. Garrido et al.
  Original research paper: Applied Microbiology and Biotechnology 73
  doi:10.1007/s00253-006-0453-z

  Abstract

• J. Wu & Z. Guo
  Original research paper: Bioconjugate Chemistry 17
  doi:10.1021/bc060103s

  Abstract

• PankoMab: a potent new generation anti-tumour MUC1 antibody

  Antje Danielczyk et al.
  Original research paper: Cancer Immunology, Immunotherapy 55
  doi:10.1007/s00262-006-0135-9

  Abstract

• Selectins – potential pharmacological targets?

  C Kneuer, C Ehrhardt, M Radomski & U Bakowsky
  Original research paper: Drug Discovery Today 11
  doi:10.1016/j.drudis.2006.09.004

  Abstract

• Non-fucosylated therapeutic antibodies as next-generation therapeutic antibodies

  Mitsuo Satoh, Shigeru Iida & Kenya Shitara
  Original research paper: Expert Opinion on Biological Therapy 6
  doi:10.1517/14712598.6.11.1161

  Abstract

• Development of recombinant protein-based influenza vaccineExpression and affinity purification of H1N1 influenza virus neuraminidase

  T Dalakouras et al.
  Original research paper: Journal of Chromatography A 1136
  doi:10.1016/j.chroma.2006.09.067

  Abstract

• Use of polysialic acid in repair of the central nervous system

  A. El maarouf, A. K. Petridis & U. Rutishauser
  Original research paper: Proceedings of the National Academy of Sciences 103
  doi:10.1073/pnas.0608036103

  Abstract

• Structure modeling, ligand binding, and binding affinity calculation (LR-MM-PBSA) of human heparanase for inhibition and drug design

  Zhigang Zhou, Maria Bates & Jeffry D. Madura
  Original research paper: Proteins: Structure, Function, and Bioinformatics 65
  doi:10.1002/prot.21065

  Abstract