Clinical/Drug Discovery
Turning down tau phosphorylation
Peter M Fischer
Original research paper: Nature Chemical Biology 4 448-449
doi:10.1038/nchembio0808-448Complementation of a pathogenic IFNGR2 misfolding mutation with modifiers of N-glycosylation
G. Vogt et al.
Original research paper: Journal of Experimental Medicine 205
doi:10.1084/jem.20071987Humans Lack iGb3 Due to the Absence of Functional iGb3-Synthase: Implications for NKT Cell Development and Transplantation
Dale Christiansen et al.
Original research paper: PLoS Biology 6
doi:10.1371/journal.pbio.0060172Enzymatic Properties of the Neuraminidase of Seasonal H1N1 Influenza Viruses Provide Insights for the Emergence of Natural Resistance to Oseltamivir
Marie-Anne Rameix-welti et al.
Original research paper: PLoS Pathogens 4
doi:10.1371/journal.ppat.1000103Hyaluronan: A constitutive regulator of chemoresistance and malignancy in cancer cells
B Toole & M Slomiany
Original research paper: Seminars in Cancer Biology 18
doi:10.1016/j.semcancer.2008.03.009Novel sugar-cholestanols as anticancer agents against peritoneal dissemination of tumor cells
Shinji Hahismoto et al.
Original research paper: Glycoconjugate Journal 25
doi:10.1007/s10719-008-9108-xUse of Glycan Targeting Antibodies To Identify Cancer-Associated Glycoproteins in Plasma of Breast Cancer Patients
Wonryeon Cho, Kwanyoung Jung & Fred E. Regnier
Original research paper: Analytical Chemistry 80
doi:10.1021/ac8008675Glypican 3 Expression in Human Nonneoplastic, Preneoplastic, and Neoplastic Tissues: A Tissue Microarray Analysis of 4,387 Tissue Samples
Daniel Baumhoer et al.
Original research paper: American Journal of Clinical Pathology 129
doi:10.1309/HCQWPWD50XHD2DW6Glycoconjugates enhanced the intracellular killing of Bacillus spores, increasing macrophage viability and activation
Olga Tarasenko et al.
Original research paper: Archives of Microbiology 189
doi:10.1007/s00203-008-0352-zDistribution of the
Gal- and the non-Gal T-antigens in the pig kidney: potential targets for rejection in pig-to-man xenotransplantationSvend Kirkeby & Hanne B Mikkelsen
Original research paper: Immunology and Cell Biology 86 363-371 (2008)
doi:10.1038/icb.2008.1Site-specific analysis ofN-glycans on haptoglobin in sera of patients with pancreatic cancer: A novel approach for the development of tumor markers
Miyako Nakano et al.
Original research paper: International Journal of Cancer 122
doi:10.1002/ijc.23364Galectin-3 Cleavage: A Novel Surrogate Marker for Matrix Metalloproteinase Activity in Growing Breast Cancers
P. Nangia-makker et al.
Original research paper: Cancer Research 67
doi:10.1158/0008-5472.CAN-07-3233Mutations of neuraminidase implicated in neuraminidase inhibitors resistance
O Ferraris & B Lina
Original research paper: Journal of Clinical Virology 41
doi:10.1016/j.jcv.2007.10.020Ex vivo glycan engineering of CD44 programs human multipotent mesenchymal stromal cell trafficking to bone
Robert Sackstein et al.
Original research paper: Nature Medicine 14 181-187 (2008)
doi:10.1038/nm1703Tetra- and hexavalent mannosides inhibit the pro-apoptotic, antiproliferative and cell surface clustering effects of concanavalin-A: Impact on MT1-MMP functions in marrow-derived mesenchymal stromal cells
S. Fortier et al.
Original research paper: Glycobiology 18
doi:10.1093/glycob/cwm133Delivery of antigen using a novel mannosylated dendrimer potentiates immunogenicityin vitro andin vivo
Kuo-Ching Sheng et al.
Original research paper: European Journal of Immunology 38
doi:10.1002/eji.200737578Carbohydrate-binding agents (CBAs) inhibit HIV-1 infection in human primary monocyte-derived macrophages (MDMs) and efficiently prevent MDM-directed viral capture and subsequent transmission to CD4+ T lymphocytes
M Pollicita et al.
Original research paper: Virology 370
doi:10.1016/j.virol.2007.08.033Galectin-1 as a potential therapeutic target in autoimmune disorders and cancer
Mariana Salatino et al.
Original research paper: Expert Opinion on Biological Therapy 8
doi:10.1517/14712598.8.1.45Glycosylation of Thrombin Activatable Fibrinolysis Inhibitor: Why Is it So Important?
F. Biscetti
Original research paper: Circulation Research 102
doi:10.1161/CIRCRESAHA.107.170498Biochemical Importance of Glycosylation in Thrombin Activatable Fibrinolysis Inhibitor
K. Buelens et al.
Original research paper: Circulation Research 102
doi:10.1161/CIRCRESAHA.107.157099HPV-16 E5 oncoprotein upregulates lipid raft components caveolin-1 and ganglioside GM1 at the plasma membrane of cervical cells
F A Suprynowicz et al.
Original research paper: Oncogene 27 1071-1078 (2007)
doi:10.1038/sj.onc.1210725Inhibition of Multidrug Resistance by AdamantylGb3, a Globotriaosylceramide Analog
M. F. De rosa et al.
Original research paper: Journal of Biological Chemistry 283
doi:10.1074/jbc.M705473200Characterization of anticoagulant heparinoids by immunoprofiling
Tessa J. Wijnhoven et al.
Original research paper: Glycoconjugate Journal 25
doi:10.1007/s10719-007-9070-zGlycan modification of the tumor antigen gp100 targets DC-SIGN to enhance dendritic cell induced antigen presentation to T cells
Corlien A. Aarnoudse et al.
Original research paper: International Journal of Cancer 122
doi:10.1002/ijc.23101Glycosylated Derivatives of Steffimycin: Insights into the Role of the Sugar Moieties for the Biological Activity
Carlos Olano et al.
Original research paper: ChemBioChem 9
doi:10.1002/cbic.200700610Novel long-lasting interferon alpha derivatives designed by glycoengineering
N Ceaglio, M Etcheverrigaray, R Kratje & M Oggero
Original research paper: Biochimie 90
doi:10.1016/j.biochi.2007.10.013Overexpression of glucosylceramide synthase in associated with multidrug resistance of leukemia cells
P Xie et al.
Original research paper: Leukemia Research 32
doi:10.1016/j.leukres.2007.07.006Synthetic GPI array to study antitoxic malaria response
Faustin Kamena et al.
Original research paper: Nature Chemical Biology 4 238-240 (2008)
doi:10.1038/nchembio.75From the Cover: IgG glycan hydrolysis by a bacterial enzyme as a therapy against autoimmune conditions
M. Collin, O. Shannon & L. Bjorck
Original research paper: Proceedings of the National Academy of Sciences 105
doi:10.1073/pnas.0711271105Targeting Hyaluronan Interactions in Malignant Gliomas and Their Drug-Resistant Multipotent Progenitors
A. G. Gilg et al.
Original research paper: Clinical Cancer Research 14
doi:10.1158/1078-0432.CCR-07-1228Identification of a GH110 Subfamily of 1,3-Galactosidases: NOVEL ENZYMES FOR REMOVAL OF THE 3GAL XENOTRANSPLANTATION ANTIGEN
Q. P. Liu et al.
Original research paper: Journal of Biological Chemistry 283
doi:10.1074/jbc.M709020200N-Glycosylation as Novel Strategy to Improve Pharmacokinetic Properties of Bispecific Single-chain Diabodies
R. Stork et al.
Original research paper: Journal of Biological Chemistry 283
doi:10.1074/jbc.M709179200High-level expression of biologically active glycoprotein hormones in Pichia pastoris strains—selection of strain GS115, and not X-33, for the production of biologically active N-glycosylated 15N-labeled phCG
Véronique Blanchard et al.
Original research paper: Glycoconjugate Journal 25
doi:10.1007/s10719-007-9082-8Glycosylation of the two O-glycosylated domains of human MUC2 mucin in patients transposed with artificial urinary bladders constructed from proximal colonic tissue
Catherine Robbe-masselot et al.
Original research paper: Glycoconjugate Journal 25
doi:10.1007/s10719-007-9079-3Design and synthesis of novel galactosylated polymers for liposomes as gene drug carriers targeting the hepatic asialoglycoprotein receptor
Si Ling Wang et al.
Original research paper: Journal of Drug Targeting 16
doi:10.1080/10611860801902609Generation of glyco-engineered Nicotiana benthamiana for the production of monoclonal antibodies with a homogeneous human-like N-glycan structure
Richard Strasser et al.
Original research paper: Plant Biotechnology Journal 6
doi:10.1111/j.1467-7652.2008.00330.xEnhancement of HIV DNA vaccine immunogenicity by the NKT cell ligand, α-galactosylceramide
Y Huang et al.
Original research paper: Vaccine 26
doi:10.1016/j.vaccine.2008.02.002Recapitulation of IVIG Anti-Inflammatory Activity with a Recombinant IgG Fc
R. M. Anthony et al.
Original research paper: Science 320
doi:10.1126/science.1154315Optimizing Glycosyltransferase Specificity via "Hot Spot" Saturation Mutagenesis Presents a Catalyst for Novobiocin Glycorandomization
G Williams, R Goff, C Zhang & J Thorson
Original research paper: Chemistry & Biology 15
doi:10.1016/j.chembiol.2008.02.017Glycosylation profiling of a therapeutic recombinant monoclonal antibody with two N-linked glycosylation sites using liquid chromatography coupled to a hybrid quadrupole time-of-flight mass spectrometer
A Lim, A Reedbogan & B Harmon
Original research paper: Analytical Biochemistry 375
doi:10.1016/j.ab.2008.01.003Change in transferrin sialylation is a potential prognostic marker for severity of acute pancreatitis
O Gornik, I Gornik, V Gasparovic & G Lauc
Original research paper: Clinical Biochemistry 41
doi:10.1016/j.clinbiochem.2008.01.026Antiobesity Effects and Improvement of Insulin Sensitivity by 1-Deoxynojirimycin in Animal Models
Won-Ho Kong et al.
Original research paper: Journal of Agricultural and Food Chemistry 56
doi:10.1021/jf073223iN-linked glycosylation of the liver cancer biomarker GP73
Pamela A. Norton et al.
Original research paper: Journal of Cellular Biochemistry 104
doi:10.1002/jcb.21610Utility of glypican-3 in differentiating hepatocellular carcinoma from other primary and metastatic lesions in FNA of the liver: an immunocytochemical study
Saverio Ligato, Daniza Mandich & Richard W Cartun
Original research paper: Modern Pathology 21 626-631 (2008)
doi:10.1038/modpathol.2008.26The Prognostic Impact of Blood Group-Related Antigen Lewis Y and the ABH Blood Groups in Resected Non-Small Cell Lung Cancer
Andreas Kuemmel et al.
Original research paper: Tumor Biology 28
doi:10.1159/000124298Physicochemical characterisation of glycoconjugate vaccines for prevention of meningococcal diseases
A Bardotti et al.
Original research paper: Vaccine 26
doi:10.1016/j.vaccine.2008.01.022Measurement of the Binding of Cholera Toxin to GM1 Gangliosides on Solid Supported Lipid Bilayer Vesicles and Inhibition by Europium (III) Chloride
Thomas L. Williams & A. Toby A. Jenkins
Original research paper: Journal of the American Chemical Society 130
doi:10.1021/ja710543xInfluenza C virus and bovine coronavirus esterase reveal a similar catalytic mechanism: new insights for drug discovery
Juliane Mayr et al.
Original research paper: Glycoconjugate Journal 25
doi:10.1007/s10719-007-9094-4Chemical conjugation of muramyl dipeptide and paclitaxel to explore the combination of immunotherapy and chemotherapy for cancer
Xuqin Li et al.
Original research paper: Glycoconjugate Journal 25
doi:10.1007/s10719-007-9095-3Polymeric glycoconjugates protect and activate macrophages to promote killing of Bacillus cereus spores during phagocytosis
Olga Tarasenko, Elizabeth Burton, Lee Soderberg & Pierre Alusta
Original research paper: Glycoconjugate Journal 25
doi:10.1007/s10719-007-9097-1Synthesis of lupane-type saponins bearing mannosyl and 3,6-branched trimannosyl residues and their evaluation as anticancer agents
P Cmoch, Z Pakulski, J Swaczynova & M Strnad
Original research paper: Carbohydrate Research 343
doi:10.1016/j.carres.2008.02.011Cowpea Mosaic Virus Capsid: A Promising Carrier for the Development of Carbohydrate Based Antitumor Vaccines
Adeline Miermont et al.
Original research paper: Chemistry - A European Journal 14
doi:10.1002/chem.200800203On-Line CE-LIF-MS Technology for the Direct Characterization of N-Linked Glycans from Therapeutic Antibodies
Lynn A. Gennaro & Oscar Salas-solano
Original research paper: Analytical Chemistry 80
doi:10.1021/ac800152hThe enzymatic activity of sialidase Neu2 is inversely regulated during in vitro myoblast hypertrophy and atrophy
A Fanzani et al.
Original research paper: Biochemical and Biophysical Research Communications 370
doi:10.1016/j.bbrc.2008.03.111Understanding of known drug-target interactions in the catalytic pocket of neuraminidase subtype N1
Maturos Malaisree et al.
Original research paper: Proteins: Structure, Function, and Bioinformatics 71
doi:10.1002/prot.21897Rapid and high-resolution glycoform profiling of recombinant human erythropoietin by capillary isoelectric focusing with whole column imaging detection
P Dou et al.
Original research paper: Journal of Chromatography A 1190
doi:10.1016/j.chroma.2008.03.001Saccharides cross-reactive with Bacillus anthracis spore glycoprotein as an anthrax vaccine component
J. Kubler-kielb et al.
Original research paper: Proceedings of the National Academy of Sciences 105
doi:10.1073/pnas.0803897105Crystal structures of oseltamivir-resistant influenza virus neuraminidase mutants
Patrick J. Collins et al.
Original research paper: Nature 453
doi:10.1038/nature06956Hyaluronan-CD44 Interaction Activates Stem Cell Marker Nanog, Stat-3-mediated MDR1 Gene Expression, and Ankyrin-regulated Multidrug Efflux in Breast and Ovarian Tumor Cells
L. Y. W. Bourguignon, K. Peyrollier, W. Xia & E. Gilad
Original research paper: Journal of Biological Chemistry 283
doi:10.1074/jbc.M800109200Adjuvant potential of archaeal synthetic glycolipid mimetics critically depends on the glyco head group structure
G D. Sprott, C. J Dicaire, J.-P. Cote & D. M Whitfield
Original research paper: Glycobiology 18
doi:10.1093/glycob/cwn038A Novel Linker Methodology for the Synthesis of Tailored Conjugate Vaccines Composed of Complex Carbohydrate Antigens and Specific T ‐Cell Peptide Epitopes
Sebastian Dziadek, Sandra Jacques & David R. Bundle
Original research paper: Chemistry - A European Journal 14
doi:10.1002/chem.200800065α-Lactosylceramide as a Novel "Sugar-Capped" CD1d Ligand for Natural Killer T Cells: Biased Cytokine Profile and Therapeutic Activities
Wenpeng Zhang et al.
Original research paper: ChemBioChem 9
doi:10.1002/cbic.200700625Odorranalectin Is a Small Peptide Lectin with Potential for Drug Delivery and Targeting
Jianxu Li et al.
Original research paper: PLoS ONE 3
doi:10.1371/journal.pone.0002381The Function of the Human Interferon- 1a Glycan Determined in Vivo
L. Dissing-olesen et al.
Original research paper: Journal of Pharmacology and Experimental Therapeutics 326
doi:10.1124/jpet.108.138263