Clinical/Drug Discovery

• Gaucher Disease Glucocerebrosidase and α-Synuclein Form a Bidirectional Pathogenic Loop in Synucleinopathies

  Joseph R. Mazzulli et al.
  Original research paper: Cell
  doi:10.1016/j.cell.2011.06.001

  Abstract

• Enhanced epithelial-mesenchymal transition-like phenotype in N-acetylglucosaminyltransferase V transgenic mouse skin promotes wound healing

  M. Terao et al.
  Original research paper: Journal of Biological Chemistry
  doi:10.1074/jbc.M111.220376

  Abstract

• Recognition of the Major Cat Allergen Fel d 1 through the Cysteine-rich Domain of the Mannose Receptor Determines Its Allergenicity

  M. Emara et al.
  Original research paper: Journal of Biological Chemistry 286
  doi:10.1074/jbc.M111.220657

  Abstract

• Oligosaccharide conjugates of Bordetella pertussis and bronchiseptica induce bactericidal antibodies, an addition to pertussis vaccine

  J. Kubler-kielb et al.
  Original research paper: Proceedings of the National Academy of Sciences 108
  doi:10.1073/pnas.1100782108

  Abstract

• Rational Design of an Aryl-C-Glycoside Catalyst from a Natural Product O-Glycosyltransferase

  Johannes Härle et al.
  Original research paper: Chemistry & Biology 18
  doi:10.1016/j.chembiol.2011.02.013

  Abstract

•  2-Glycoprotein I and Protection from Anti-SSA/Ro60-Associated Cardiac Manifestations of Neonatal Lupus

  J. H. Reed et al.
  Original research paper: The Journal of Immunology 187
  doi:10.4049/jimmunol.1100122

  Abstract

• Acceptable changes in quality attributes of glycosylated biopharmaceuticals

  Martin Schiestl et al.
  Original research paper: Nature Biotechnology 29 310-312 (2011)
  doi:10.1038/nbt.1839

  Abstract

• Design and synthesis of O-GlcNAcase inhibitors via ‘click chemistry’ and biological evaluations

  Tiehai Li et al.
  Original research paper: Carbohydrate Research 346
  doi:10.1016/j.carres.2011.03.026

  Abstract

• Proteomic analysis identifies galectin-1 as a predictive biomarker for relapsed/refractory disease in classical Hodgkin lymphoma

  P. Kamper et al.
  Original research paper: Blood 117
  doi:10.1182/blood-2010-12-327346

  Abstract

• Uptake of unnatural trehalose analogs as a reporter for Mycobacterium tuberculosis

  Keriann M Backus et al.
  Original research paper: Nature Chemical Biology 7
  doi:10.1038/nchembio.539

  Abstract

• Cell-Penetrant, Nanomolar O-GlcNAcase Inhibitors Selective against Lysosomal Hexosaminidases

  Helge C. Dorfmueller et al.
  Original research paper: Chemistry & Biology 17
  doi:10.1016/j.chembiol.2010.09.014

  Abstract

• Alleviating Cancer Drug Toxicity by Inhibiting a Bacterial Enzyme

  B. D. Wallace et al.
  Original research paper: Science 330
  doi:10.1126/science.1191175

  Abstract

• Safe, Efficient, and Reproducible Gene Therapy of the Brain in the Dog Models of Sanfilippo and Hurler Syndromes

  N Matthew Ellinwood et al.
  Original research paper: Molecular Therapy 19 251-259 (2010)
  doi:10.1038/mt.2010.265

  Abstract

• Enzymatic synthesis of vancomycin derivatives using galactosyltransferase and sialyltransferase

  Tae-Jin Oh et al.
  Original research paper: The Journal of Antibiotics 64 103-109 (2010)
  doi:10.1038/ja.2010.131

  Abstract

• O-GlcNAc Transferase Catalyzes Site-Specific Proteolysis of HCF-1

  Francesca Capotosti et al.
  Original research paper: Cell 144
  doi:10.1016/j.cell.2010.12.030

  Abstract

• Crosstalk between O-GlcNAcylation and proteolytic cleavage regulates the host cell factor-1 maturation pathway

  S. Daou et al.
  Original research paper: Proceedings of the National Academy of Sciences 108
  doi:10.1073/pnas.1013822108

  Abstract

• Ex Vivo Activity of Cardiac Glycosides in Acute Leukaemia

  Helene Hallböök et al.
  Original research paper: PLoS ONE 6
  doi:10.1371/journal.pone.0015718

  Abstract

• Mouse and human iNKT cell agonist β-mannosylceramide reveals a distinct mechanism of tumor immunity

  Jessica J. O’konek et al.
  Original research paper: Journal of Clinical Investigation 121
  doi:10.1172/JCI42314

  Abstract

• Hijacking a biosynthetic pathway yields a glycosyltransferase inhibitor within cells

  Tracey M Gloster et al.
  Original research paper: Nature Chemical Biology 7 174-181 (2011)
  doi:10.1038/nchembio.520

  Abstract