Disease
Overexpression of ST6GalNAcV, a ganglioside-specific 2,6-sialyltransferase, inhibits glioma growth in vivo
R. A. Kroes et al.
Original research paper: Proceedings of the National Academy of Sciences 107
doi:10.1073/pnas.0909862107Nm23-H1 suppresses hepatocarcinoma cell adhesion and migration on fibronectin by modulating glycosylation of integrin beta1
Shangyang She et al.
Original research paper: Journal of Experimental & Clinical Cancer Research 29
doi:10.1186/1756-9966-29-93SRD5A3 Is Required for Converting Polyprenol to Dolichol and Is Mutated in a Congenital Glycosylation Disorder
Vincent Cantagrel et al.
Original research paper: Cell 142
doi:10.1016/j.cell.2010.06.001Envelope glycans of immunodeficiency virions are almost entirely oligomannose antigens
K. J. Doores et al.
Original research paper: Proceedings of the National Academy of Sciences 107
doi:10.1073/pnas.1006498107Tumor Cells Secrete Galectin-1 to Enhance Endothelial Cell Activity
V. L. Thijssen et al.
Original research paper: Cancer Research 70
doi:10.1158/0008-5472.CAN-09-4150Involvement of ST6Gal I in the biosynthesis of a unique human colon cancer biomarker candidate, 2,6-sialylated blood group type 2H (ST2H) antigen
H. Korekane et al.
Original research paper: Journal of Biochemistry 148
doi:10.1093/jb/mvq077Sialylated and O-glycosidically linked glycans in prion protein deposits in a case of Gerstmann-Sträussler-Scheinker disease
Viviana Zomosa-signoret et al.
Original research paper: Neuropathology
doi:10.1111/j.1440-1789.2010.01145.xNovel ganglioside found in adenocarcinoma cells of Lewis-negative patients
K. Shida et al.
Original research paper: Glycobiology 20
doi:10.1093/glycob/cwq108Glycan Encapsulated Gold Nanoparticles Selectively Inhibit Shiga Toxins 1 and 2
Ashish A. Kulkarni et al.
Original research paper: Bioconjugate Chemistry 21
doi:10.1021/bc100095wIgG Fc N Glycosylation Changes in Lambert-Eaton Myasthenic Syndrome and Myasthenia Gravis
Maurice H. J. Selman et al.
Original research paper: Journal of Proteome Research
doi:10.1021/pr1004373Self-poisoning of Mycobacterium tuberculosis by targeting GlgE in an α-glucan pathway
Rainer Kalscheuer et al.
Original research paper: Nature Chemical Biology 6
doi:10.1038/nchembio.340MGAT5 alters the severity of multiple sclerosis
B. Brynedal et al.
Original research paper: Journal of Neuroimmunology 220
doi:10.1016/j.jneuroim.2010.01.003Analysis and metabolic engineering of lipid-linked oligosaccharides in glycosylation-deficient CHO cells
Meredith B. Jones, Noboru Tomiya, Michael J. Betenbaugh & Sharon S. Krag
Original research paper: Biochemical and Biophysical Research Communications 395
doi:10.1016/j.bbrc.2010.03.117Polysialic acid affects pathophysiological consequences of status epilepticus
Anton Pekcec, Birgit Weinhold, Rita Gerardy-schahn & Heidrun Potschka
Original research paper: NeuroReport 21
doi:10.1097/WNR.0b013e328338616dGlycomic Analysis of Sialic Acid Linkages in Glycans Derived from Blood Serum Glycoproteins
William R. Alley & Milos V. Novotny
Original research paper: Journal of Proteome Research 9
doi:10.1021/pr901210rDiagnostic Value of the Hemopexin N-Glycan Profile in Hepatocellular Carcinoma Patients
E. N. Debruyne et al.
Original research paper: Clinical Chemistry 56
doi:10.1373/clinchem.2009.139295Structural Characterization of Glycans on Omega-1, a Major Egg Glycoprotein That Drives Th2 Responses
Moniek H. J. Meevissen et al.
Original research paper: Journal of Proteome Research 9
doi:10.1021/pr100081cCancer Biomarkers Defined by Autoantibody Signatures to Aberrant O-Glycopeptide Epitopes
H. H. Wandall et al.
Original research paper: Cancer Research 70
doi:10.1158/0008-5472.CAN-09-2893Genetically-Defined Deficiency of Mannose-Binding Lectin Is Associated with Protection after Experimental Stroke in Mice and Outcome in Human Stroke
Alvaro Cervera et al.
Original research paper: PLoS ONE 5
doi:10.1371/journal.pone.0008433A Multifunctional Mannosyltransferase Family in Candida albicans Determines Cell Wall Mannan Structure and Host-Fungus Interactions
H. M. Mora-montes et al.
Original research paper: Journal of Biological Chemistry 285
doi:10.1074/jbc.M109.081513Enhancement of the adhesive and spreading potentials of ovarian carcinoma RMG-1 cells due to increased expression of integrin α5β1 with the Lewis Y-structure on transfection of the α1,2-fucosyltransferase gene
Li-Mei Yan et al.
Original research paper: Biochimie 92
doi:10.1016/j.biochi.2010.02.012Can any lessons be learned from the ambiguous glycan binding of PfEMP1 domains?
Madeleine Dahlbäck, Morten A. Nielsen & Ali Salanti
Original research paper: Trends in Parasitology 26
doi:10.1016/j.pt.2010.02.002A novel lectin with highly potent antiproliferative and HIV-1 reverse transcriptase inhibitory activities from the edible wild mushroom Russula delica
Shuang Zhao et al.
Original research paper: Glycoconjugate Journal 27
doi:10.1007/s10719-009-9274-5A mouse model of chondrocyte-specific somatic mutation reveals a role for Ext1 loss of heterozygosity in multiple hereditary exostoses
K. Matsumoto, F. Irie, S. Mackem & Y. Yamaguchi
Original research paper: Proceedings of the National Academy of Sciences 107
doi:10.1073/pnas.0914642107Tumour-associated glycan modifications of antigen enhance MGL2 dependent uptake and MHC class I restricted CD8 T cell responses
Satwinder Kaur Singh et al.
Original research paper: International Journal of Cancer
doi:10.1002/ijc.25458β1,4-Galactosyltransferase-I contributes to the inflammatory processes in synovial tissue of patients with rheumatoid arthritis
Youhua Wang et al.
Original research paper: Inflammation Research 59
doi:10.1007/s00011-010-0217-1Identification of Siglec-9 as the receptor for MUC16 on human NK cells, B cells, and monocytes
Jennifer A. Belisle et al.
Original research paper: Molecular Cancer 9
doi:10.1186/1476-4598-9-118Recognition of Galactose-Deficient -Glycans in the Hinge Region of IgA1 by -Acetylgalactosamine-Specific Snail Lectins: A Comparative Binding Study
Michelle M. Gomes et al.
Original research paper: Biochemistry 49
doi:10.1021/bi9019498Microvirin, a Novel (1,2)-Mannose-specific Lectin Isolated from Microcystis aeruginosa, Has Anti-HIV-1 Activity Comparable with That of Cyanovirin-N but a Much Higher Safety Profile
D. Huskens et al.
Original research paper: Journal of Biological Chemistry 285
doi:10.1074/jbc.M110.128546GMI-1070, a novel pan-selectin antagonist, reverses acute vascular occlusions in sickle cell mice
J. Chang et al.
Original research paper: Blood 116
doi:10.1182/blood-2009-12-260513Glycan Analysis and Influenza A Virus Infection of Primary Swine Respiratory Epithelial Cells: THE IMPORTANCE OF NeuAc 2-6 GLYCANS
A. C. Bateman et al.
Original research paper: Journal of Biological Chemistry 285
doi:10.1074/jbc.M110.115998Tumor suppressor p16INK4a: Downregulation of galectin-3, an endogenous competitor of the pro-anoikis effector galectin-1, in a pancreatic carcinoma model
Hugo Sanchez-ruderisch et al.
Original research paper: FEBS Journal 277
doi:10.1111/j.1742-4658.2010.07764.xGalectin-3 Is a Candidate Biomarker for Amyotrophic Lateral Sclerosis: Discovery by a Proteomics Approach
Jian-Ying Zhou et al.
Original research paper: Journal of Proteome Research 9
doi:10.1021/pr100409rGalectin-3 Promotes Chronic Activation of K-Ras and Differentiation Block in Malignant Thyroid Carcinomas
R. Levy, M. Grafi-cohen, Z. Kraiem & Y. Kloog
Original research paper: Molecular Cancer Therapeutics 9
doi:10.1158/1535-7163.MCT-10-0262Cytoskeletal keratin glycosylation protects epithelial tissue from injury
Nam-On Ku, Diana M. Toivola, Pavel Strnad & M. Bishr Omary
Original research paper: Nature Cell Biology 12
doi:10.1038/ncb2091The Novel Membrane Protein TMEM59 Modulates Complex Glycosylation, Cell Surface Expression, and Secretion of the Amyloid Precursor Protein
S. Ullrich et al.
Original research paper: Journal of Biological Chemistry 285
doi:10.1074/jbc.M109.055608Glycosylation Patterns of HIV-1 gp120 Depend on the Type of Expressing Cells and Affect Antibody Recognition
M. Raska et al.
Original research paper: Journal of Biological Chemistry 285
doi:10.1074/jbc.M109.085472The glycosylation of human synovial lubricin: implications for its role in inflammation
Ruby P. Estrella, John M. Whitelock, Nicolle H. Packer & Niclas G. Karlsson
Original research paper: Biochemical Journal 429
doi:10.1042/BJ20100360Identification and Characterization of the Carbohydrate Ligands Recognized by Pertussis Toxin via a Glycan Microarray and Surface Plasmon Resonance
Scott H. Millen et al.
Original research paper: Biochemistry 49
doi:10.1021/bi100474zA polysaccharide from the human commensal Bacteroides fragilis protects against CNS demyelinating disease
J Ochoa-repáraz et al.
Original research paper: Mucosal Immunology 3
doi:10.1038/mi.2010.29The ABC of glycosylation
Paola Perego, Laura Gatti & Giovanni L. Beretta
Original research paper: Nature Reviews Cancer 10 523 (2010)
doi:10.1038/nrc2789-c1Assessment of Tumor Metastasis by the Direct Determination of Cell-Membrane Sialic Acid Expression
Akira Matsumoto et al.
Original research paper: Angewandte Chemie International Edition 49
doi:10.1002/anie.201001220Doxorubicin attached to HPMA copolymer via amide bond modifies the glycosylation pattern of EL4 cells
Lubomir Kovar et al.
Original research paper: Tumor Biology 31
doi:10.1007/s13277-010-0019-7Ganglioside GD3 Enhances Adhesion Signals and Augments Malignant Properties of Melanoma Cells by Recruiting Integrins to Glycolipid-enriched Microdomains
Y. Ohkawa et al.
Original research paper: Journal of Biological Chemistry 285
doi:10.1074/jbc.M109.087791Potential of carbohydrate-binding agents as therapeutics against enveloped viruses
K. O. François & J. Balzarini
Original research paper: Medicinal Research Reviews
doi:10.1002/med.20216Interaction between circulating galectin-3 and cancer-associated MUC1 enhances tumour cell homotypic aggregation and prevents anoikis
Qicheng Zhao et al.
Original research paper: Molecular Cancer 9
doi:10.1186/1476-4598-9-154Does Glycosylation as a modifier of Original Antigenic Sin explain the case age distribution and unusual toxicity in pandemic novel H1N1 influenza?
Tom Reichert et al.
Original research paper: BMC Infectious Diseases 10
doi:10.1186/1471-2334-10-5N-Glycomic Changes in Human Breast Carcinoma MCF-7 and T-Lymphoblastoid Cells After Treatment with Herceptin and Herceptin/Lipoplex
Erika Lattová, Boguslaw Tomanek, Dorota Bartusik & Hélène Perreault
Original research paper: Journal of Proteome Research 9
doi:10.1021/pr9010266Glycosaminoglycan-induced activation of the β-secretase (BACE1) of Alzheimer’s disease
David W. Klaver et al.
Original research paper: Journal of Neurochemistry 112
doi:10.1111/j.1471-4159.2010.06571.xMass Spectrometric Identification of Aberrantly Glycosylated Human Apolipoprotein C-III Peptides in Urine from Schistosoma mansoni-infected Individuals
C. I. A. Balog et al.
Original research paper: Molecular & Cellular Proteomics 9
doi:10.1074/mcp.M900537-MCP200Hyaluronic acid inhibits nitric oxide-induced apoptosis and dedifferentiation of articular chondrocytes in vitro
Hao Peng et al.
Original research paper: Inflammation Research 59
doi:10.1007/s00011-010-0156-xA severe human metabolic disease caused by deficiency of the endoplasmatic mannosyltransferase hALG11 leads to congenital disorder of glycosylation-Ip
N. Rind et al.
Original research paper: Human Molecular Genetics 19
doi:10.1093/hmg/ddq016Loss of syndecan-1 is associated with malignant conversion in skin carcinogenesis
Mary Ann Stepp et al.
Original research paper: Molecular Carcinogenesis
doi:10.1002/mc.20609Polymorphisms in the sialic acid-binding immunoglobulin-like lectin-8 (Siglec-8) gene are associated with susceptibility to asthma
Pei-Song Gao et al.
Original research paper: European Journal of Human Genetics (2010)
doi:10.1038/ejhg.2009.239Heparan sulfate mediates amyloid-beta internalization and cytotoxicity
E. Sandwall et al.
Original research paper: Glycobiology 20
doi:10.1093/glycob/cwp2051,2-Fucosylated and -N-acetylgalactosaminylated prostate-specific antigen as an efficient marker of prostatic cancer
K. Fukushima, T. Satoh, S. Baba & K. Yamashita
Original research paper: Glycobiology 20
doi:10.1093/glycob/cwp197CD44 and hyaluronan promote invasive growth of B35 neuroblastoma cells into the brain
Annette Pusch et al.
Original research paper: Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1803
doi:10.1016/j.bbamcr.2009.12.003Serum anti-glycan antibodies predict complicated Crohn's disease behavior: A cohort study
Florian Rieder et al.
Original research paper: Inflammatory Bowel Diseases
doi:10.1002/ibd.21179Human monoclonal antibody GNX-8 directed to extended type 1 chain: Specific binding to human colorectal cancer
Mei-Chun Yang et al.
Original research paper: International Journal of Cancer
doi:10.1002/ijc.25131Mucins in ovarian cancer diagnosis and therapy
Subhash C Chauhan, Deepak Kumar & Meena Jaggi
Original research paper: Journal of Ovarian Research 2
doi:10.1186/1757-2215-2-21Association of plasma soluble E-selectin and adiponectin with carotid plaque in patients with systemic lupus erythematosus
Harmony R. Reynolds et al.
Original research paper: Atherosclerosis 210
doi:10.1016/j.atherosclerosis.2009.12.007O-Mannosyl Phosphorylation of Alpha-Dystroglycan Is Required for Laminin Binding
T. Yoshida-moriguchi et al.
Original research paper: Science 327
doi:10.1126/science.1180512The Bisecting GlcNAc on N-Glycans Inhibits Growth Factor Signaling and Retards Mammary Tumor Progression
Y. Song et al.
Original research paper: Cancer Research 70
doi:10.1158/0008-5472.CAN-09-2719Duality of the carbohydrate-recognition system of Pseudomonas aeruginosa-II lectin (PA-IIL)
Albert M. Wu, Yu-Ping Gong, Chia-Chen Li & Nechama Gilboa-garber
Original research paper: FEBS Letters 584
doi:10.1016/j.febslet.2010.04.026Increased Expression of -N-Acetylglucosaminidase in Erythrocytes From Individuals With Pre-diabetes and Diabetes
K. Park, C. D. Saudek & G. W. Hart
Original research paper: Diabetes 59
doi:10.2337/db09-1086Effect of Human Colorectal Carcinogenesis on the Neural Cell Adhesion Molecule Expression and Polysialylation
A. Fernández-briera, I. García-parceiro, E. Cuevas & E. Gil-martín
Original research paper: Oncology 78
doi:10.1159/000313699β1,4-Galactosyltransferase V regulates self-renewal of glioma-initiating cell
Yuanyan Wei et al.
Original research paper: Biochemical and Biophysical Research Communications 396
doi:10.1016/j.bbrc.2010.04.110HIV-1 and pattern-recognition receptors: a marriage of convenience
Michel J Tremblay
Original research paper: Nature Immunology 11
doi:10.1038/ni0510-363HIV-1 exploits innate signaling by TLR8 and DC-SIGN for productive infection of dendritic cells
Sonja I Gringhuis et al.
Original research paper: Nature Immunology 11
doi:10.1038/ni.1858Capture of influenza by medullary dendritic cells via SIGN-R1 is essential for humoral immunity in draining lymph nodes
Santiago F Gonzalez et al.
Original research paper: Nature Immunology 11
doi:10.1038/ni.1856
