Disease

• Genetics and the environment converge to dysregulate N-glycosylation in multiple sclerosis

  Haik Mkhikian et al.
  Original research paper: Nature Communications 2 (2011)
  doi:10.1038/ncomms1333

  Abstract

• Gaucher Disease Glucocerebrosidase and α-Synuclein Form a Bidirectional Pathogenic Loop in Synucleinopathies

  Joseph R. Mazzulli et al.
  Original research paper: Cell
  doi:10.1016/j.cell.2011.06.001

  Abstract

• A novel strategy for evasion of NK cell immunity by tumours expressing core2 O-glycans

  Shigeru Tsuboi et al.
  Original research paper: The EMBO Journal (2011)
  doi:10.1038/emboj.2011.215

  Abstract

• Heparan sulfate 6-O-sulfotransferase 1, a gene involved in extracellular sugar modifications, is mutated in patients with idiopathic hypogonadotrophic hypogonadism

  J. Tornberg et al.
  Original research paper: Proceedings of the National Academy of Sciences
  doi:10.1073/pnas.1102284108

  Abstract

• Structure and function of the complete internal fusion loop from Ebolavirus glycoprotein 2

  S. M. Gregory et al.
  Original research paper: Proceedings of the National Academy of Sciences
  doi:10.1073/pnas.1104760108

  Abstract

• Galectin-9 binding to cell surface protein disulfide isomerase regulates the redox environment to enhance T-cell migration and HIV entry

  S. Bi, P. W. Hong, B. Lee & L. G. Baum
  Original research paper: Proceedings of the National Academy of Sciences 108
  doi:10.1073/pnas.1017954108

  Abstract

• Enhanced epithelial-mesenchymal transition-like phenotype in N-acetylglucosaminyltransferase V transgenic mouse skin promotes wound healing

  M. Terao et al.
  Original research paper: Journal of Biological Chemistry
  doi:10.1074/jbc.M111.220376

  Abstract

• Subtype Specific Elevated Expression of Hyaluronidase-1 (HYAL-1) in Epithelial Ovarian Cancer

  Paule Héléna Yoffou et al.
  Original research paper: PLoS ONE 6
  doi:10.1371/journal.pone.0020705

  Abstract

• Genome-wide association study identifies two loci strongly affecting transferrin glycosylation

  Z. Kutalik et al.
  Original research paper: Human Molecular Genetics
  doi:10.1093/hmg/ddr272

  Abstract

• Characterization of Glycosylation Profiles of HIV-1 Transmitted/Founder Envelopes by Mass Spectrometry

  E. P. Go et al.
  Original research paper: Journal of Virology
  doi:10.1128/JVI.05053-11

  Abstract

• Recognition of the Major Cat Allergen Fel d 1 through the Cysteine-rich Domain of the Mannose Receptor Determines Its Allergenicity

  M. Emara et al.
  Original research paper: Journal of Biological Chemistry 286
  doi:10.1074/jbc.M111.220657

  Abstract

• Zebrafish Fukutin family proteins link the unfolded protein response with dystroglycanopathies

  Y.-Y. Lin et al.
  Original research paper: Human Molecular Genetics 20
  doi:10.1093/hmg/ddr059

  Abstract

• Heparan Sulphate Proteoglycan and the Low-Density Lipoprotein Receptor-Related Protein 1 Constitute Major Pathways for Neuronal Amyloid-  Uptake

  T. Kanekiyo et al.
  Original research paper: Journal of Neuroscience 31
  doi:10.1523/JNEUROSCI.5491-10.2011

  Abstract

• Broadly neutralizing DNA vaccine with specific mutation alters the antigenicity and sugar-binding activities of influenza hemagglutinin

  M.-W. Chen et al.
  Original research paper: Proceedings of the National Academy of Sciences 108
  doi:10.1073/pnas.1019744108

  Abstract

• Viral induction and targeted inhibition of galectin-1 in EBV+ posttransplant lymphoproliferative disorders

  J. Ouyang et al.
  Original research paper: Blood 117
  doi:10.1182/blood-2010-11-320481

  Abstract

• Anti-NeuGcGM3 Antibodies, Actively Elicited by Idiotypic Vaccination in Nonsmall Cell Lung Cancer Patients, Induce Tumor Cell Death by an Oncosis-Like Mechanism

  A. M. Hernandez et al.
  Original research paper: The Journal of Immunology 186
  doi:10.4049/jimmunol.1000609

  Abstract

• Posttranslational Modification of Pili upon Cell Contact Triggers N. meningitidis Dissemination

  J. Chamot-rooke et al.
  Original research paper: Science 331
  doi:10.1126/science.1200729

  Abstract

• Biochemical correlation of activity of the α-dystroglycan-modifying glycosyltransferase POMGnT1 with mutations in muscle-eye-brain disease

  Josef Voglmeir et al.
  Original research paper: Biochemical Journal 436
  doi:10.1042/BJ20101059

  Abstract

• Peptidoglycan recognition proteins kill bacteria by activating protein-sensing two-component systems

  Des Raj Kashyap et al.
  Original research paper: Nature Medicine 17 676-683 (2011)
  doi:10.1038/nm.2357

  Abstract

• Alterations in glycopeptides associated with herceptin treatment of human breast carcinoma MCF-7 and T-lymphoblastoid cells

  E. Lattova et al.
  Original research paper: Molecular & Cellular Proteomics
  doi:10.1074/mcp.M111.007765

  Abstract

• Galactose-modified iNKT cell agonists stabilized by an induced fit of CD1d prevent tumour metastasis

  Sandrine Aspeslagh et al.
  Original research paper: The EMBO Journal 30 2294-2305 (2011)
  doi:10.1038/emboj.2011.145

  Abstract

• Structural basis for immunization with postfusion respiratory syncytial virus fusion F glycoprotein (RSV F) to elicit high neutralizing antibody titers

  K. A. Swanson et al.
  Original research paper: Proceedings of the National Academy of Sciences 108
  doi:10.1073/pnas.1106536108

  Abstract

• The Conformation and Function of a Multimodular Glycogen-Degrading Pneumococcal Virulence Factor

  Alicia Lammerts van bueren et al.
  Original research paper: Structure 19
  doi:10.1016/j.str.2011.03.001

  Abstract

• Advanced Glycation End Product Recognition by the Receptor for AGEs

  Jing Xue et al.
  Original research paper: Structure 19
  doi:10.1016/j.str.2011.02.013

  Abstract

• Screening of Escherichia coli Species Biodiversity Reveals New Biofilm-Associated Antiadhesion Polysaccharides

  O. Rendueles et al.
  Original research paper: mBio 2
  doi:10.1128/mBio.00043-11

  Abstract

• Extensive mannose phosphorylation on leukemia inhibitory factor (LIF) controls its extracellular levels by multiple mechanisms

  J. Barnes et al.
  Original research paper: Journal of Biological Chemistry
  doi:10.1074/jbc.M111.221432

  Abstract

•  2-Glycoprotein I and Protection from Anti-SSA/Ro60-Associated Cardiac Manifestations of Neonatal Lupus

  J. H. Reed et al.
  Original research paper: The Journal of Immunology 187
  doi:10.4049/jimmunol.1100122

  Abstract

• Lack of Galectin-3 Disturbs Mesenteric Lymph Node Homeostasis and B Cell Niches in the Course of Schistosoma mansoni Infection

  Felipe L. Oliveira et al.
  Original research paper: PLoS ONE 6
  doi:10.1371/journal.pone.0019216

  Abstract

• Two gene clusters co-ordinate for a functional N-acetylglucosamine catabolic pathway in Vibrio cholerae

  Swagata Ghosh et al.
  Original research paper: Molecular Microbiology 80
  doi:10.1111/j.1365-2958.2011.07664.x

  Abstract

• L-Fucose utilization provides Campylobacter jejuni with a competitive advantage

  M. Stahl et al.
  Original research paper: Proceedings of the National Academy of Sciences 108
  doi:10.1073/pnas.1014125108

  Abstract

• Regulation of Sialyl Lewis Antigen Expression in Colon Cancer Cells by Sialidase NEU4

  K. Shiozaki et al.
  Original research paper: Journal of Biological Chemistry 286
  doi:10.1074/jbc.M111.231191

  Abstract

• P-glycoprotein mediates resistance to A3 adenosine receptor agonist 2-chloro-N6-(3-iodobenzyl)-adenosine-5′-N-methyluronamide in human leukemia cells

  Petr Mlejnek, Petr Dolezel & Petr Kosztyu
  Original research paper: Journal of Cellular Physiology
  doi:10.1002/jcp.22775

  Abstract

• Proteomic analysis identifies galectin-1 as a predictive biomarker for relapsed/refractory disease in classical Hodgkin lymphoma

  P. Kamper et al.
  Original research paper: Blood 117
  doi:10.1182/blood-2010-12-327346

  Abstract

• Role of Glomerular Proteoglycans in IgA Nephropathy

  Kerstin Ebefors et al.
  Original research paper: PLoS ONE 6
  doi:10.1371/journal.pone.0018575

  Abstract

• Introduction of N-Linked Glycans in the Lectin Domain of Surfactant Protein D: IMPACT ON INTERACTIONS WITH INFLUENZA A VIRUSES

  M. Van eijk et al.
  Original research paper: Journal of Biological Chemistry 286
  doi:10.1074/jbc.M111.224469

  Abstract

• HIV-1 p17 Matrix Protein Interacts with Heparan Sulfate Side Chain of CD44v3, Syndecan-2, and Syndecan-4 Proteoglycans Expressed on Human Activated CD4+ T Cells Affecting Tumor Necrosis Factor   and Interleukin 2 Production

  M. A. De francesco, M. Baronio & C. Poiesi
  Original research paper: Journal of Biological Chemistry 286
  doi:10.1074/jbc.M110.191270

  Abstract

• Structure and Immunological Characterization of the Capsular Polysaccharide of a Pyrogenic Liver Abscess Caused by Klebsiella pneumoniae: ACTIVATION OF MACROPHAGES THROUGH TOLL-LIKE RECEPTOR 4

  F.-L. Yang et al.
  Original research paper: Journal of Biological Chemistry 286
  doi:10.1074/jbc.M111.222091

  Abstract

• Development of glycoprotein capture based label-free method for the high-throughput screening of differential glycoproteins in hepatocellular carcinoma

  R. Chen et al.
  Original research paper: Molecular & Cellular Proteomics
  doi:10.1074/mcp.M110.006445

  Abstract

• Structural and functional impairments of polysialic acid by a mutated polysialyltransferase found in Schizophrenia

  R. Isomura, K. Kitajima & C. Sato
  Original research paper: Journal of Biological Chemistry
  doi:10.1074/jbc.M111.221143

  Abstract

• Uptake of unnatural trehalose analogs as a reporter for Mycobacterium tuberculosis

  Keriann M Backus et al.
  Original research paper: Nature Chemical Biology 7
  doi:10.1038/nchembio.539

  Abstract

• Heparan sulfate/heparin promotes transthyretin fibrillization through selective binding to a basic motif in the protein

  F. Noborn et al.
  Original research paper: Proceedings of the National Academy of Sciences 108
  doi:10.1073/pnas.1101194108

  Abstract

• Design of Glycopeptides Used to Investigate Class II MHC Binding and T-Cell Responses Associated with Autoimmune Arthritis

  Ida E. Andersson et al.
  Original research paper: PLoS ONE 6
  doi:10.1371/journal.pone.0017881

  Abstract

• Diabetes results in structural alteration of chondroitin sulfate/dermatan sulfate in the rat kidney: effects on the binding to extracellular matrix components

  D. Joladarashi, P. V. Salimath & N. D. Chilkunda
  Original research paper: Glycobiology 21
  doi:10.1093/glycob/cwr029

  Abstract

• G6PC3 mutations are associated with a major defect of glycosylation: a novel mechanism for neutrophil dysfunction

  B. Hayee et al.
  Original research paper: Glycobiology 21
  doi:10.1093/glycob/cwr023

  Abstract

• Loss of intestinal core 1–derived O-glycans causes spontaneous colitis in mice

  Jianxin Fu et al.
  Original research paper: Journal of Clinical Investigation 121
  doi:10.1172/JCI45538

  Abstract

• Proteomics in Ménière disease

  Giuseppe Chiarella et al.
  Original research paper: Journal of Cellular Physiology
  doi:10.1002/jcp.22737

  Abstract

• Quantitative N-linked glycoproteomics of myocardial ischemia / reperfusion injury reveals early remodeling in the extracellular environment

  B. L. Parker et al.
  Original research paper: Molecular & Cellular Proteomics
  doi:10.1074/mcp.M110.006833

  Abstract

• Targeted Identification of Metastasis-associated Cell-surface Sialoglycoproteins in Prostate Cancer

  L. Yang et al.
  Original research paper: Molecular & Cellular Proteomics 10
  doi:10.1074/mcp.M110.007294

  Abstract

• SIRT3 Deacetylates Mitochondrial 3-Hydroxy-3-Methylglutaryl CoA Synthase 2 and Regulates Ketone Body Production

  Tadahiro Shimazu et al.
  Original research paper: Cell Metabolism 12
  doi:10.1016/j.cmet.2010.11.003

  Abstract

• Fungal Recognition Enhances Mannose Receptor Shedding through Dectin-1 Engagement

  U. Gazi et al.
  Original research paper: Journal of Biological Chemistry 286
  doi:10.1074/jbc.M110.185025

  Abstract

• Protein O-mannosyltransferases participate in ER protein quality control

  V. Goder & A. Melero
  Original research paper: Journal of Cell Science 124
  doi:10.1242/jcs.072181

  Abstract

• The GD1a glycan is a cellular receptor for adenoviruses causing epidemic keratoconjunctivitis

  Emma C Nilsson et al.
  Original research paper: Nature Medicine 17 105-109 (2010)
  doi:10.1038/nm.2267

  Abstract

• Alleviating Cancer Drug Toxicity by Inhibiting a Bacterial Enzyme

  B. D. Wallace et al.
  Original research paper: Science 330
  doi:10.1126/science.1191175

  Abstract

• Safe, Efficient, and Reproducible Gene Therapy of the Brain in the Dog Models of Sanfilippo and Hurler Syndromes

  N Matthew Ellinwood et al.
  Original research paper: Molecular Therapy 19 251-259 (2010)
  doi:10.1038/mt.2010.265

  Abstract

• Milk sialyllactose influences colitis in mice through selective intestinal bacterial colonization

  A. Fuhrer et al.
  Original research paper: Journal of Experimental Medicine 207
  doi:10.1084/jem.20101098

  Abstract

• Enzymatic synthesis of vancomycin derivatives using galactosyltransferase and sialyltransferase

  Tae-Jin Oh et al.
  Original research paper: The Journal of Antibiotics 64 103-109 (2010)
  doi:10.1038/ja.2010.131

  Abstract

• Syndecan-1 Promotes Staphylococcus aureus Corneal Infection by Counteracting Neutrophil-mediated Host Defense

  A. Hayashida, S. Amano & P. W. Park
  Original research paper: Journal of Biological Chemistry 286
  doi:10.1074/jbc.M110.185165

  Abstract

• Altered mRNA expressions of sialyltransferases in human gastric cancer tissues

  Li Jun et al.
  Original research paper: Medical Oncology
  doi:10.1007/s12032-010-9771-1

  Abstract

• Specific posttranslational modification regulates early events in mammary carcinoma formation

  H.-B. Guo et al.
  Original research paper: Proceedings of the National Academy of Sciences 107
  doi:10.1073/pnas.1013405107

  Abstract

• Glycosylation Focuses Sequence Variation in the Influenza A Virus H1 Hemagglutinin Globular Domain

  Suman R. Das et al.
  Original research paper: PLoS Pathogens 6
  doi:10.1371/journal.ppat.1001211

  Abstract

• Dysregulation of TIM-3-Galectin-9 Pathway in the Cystic Fibrosis Airways

  I. Vega-carrascal et al.
  Original research paper: The Journal of Immunology 186
  doi:10.4049/jimmunol.1003187

  Abstract

• Three Sialidases: Three Different Products

  Guogang Xu et al.
  Original research paper: Journal of the American Chemical Society 133
  doi:10.1021/ja110733q

  Abstract

• Suppressive Effect of Bacterial Polysaccharides on BAFF System Is Responsible for Their Poor Immunogenicity

  S. Kanswal et al.
  Original research paper: The Journal of Immunology 186
  doi:10.4049/jimmunol.1002976

  Abstract

• Synthetic UDP-Furanoses as Potent Inhibitors of Mycobacterial Galactan Biogenesis

  Pauline Peltier et al.
  Original research paper: Chemistry & Biology 17
  doi:10.1016/j.chembiol.2010.10.014

  Abstract

• Ex Vivo Activity of Cardiac Glycosides in Acute Leukaemia

  Helene Hallböök et al.
  Original research paper: PLoS ONE 6
  doi:10.1371/journal.pone.0015718

  Abstract

• Mouse and human iNKT cell agonist β-mannosylceramide reveals a distinct mechanism of tumor immunity

  Jessica J. O’konek et al.
  Original research paper: Journal of Clinical Investigation 121
  doi:10.1172/JCI42314

  Abstract

• Meningococcal Group W-135 and Y Capsular Polysaccharides Paradoxically Enhance Activation of the Alternative Pathway of Complement

  S. Ram, L. A. Lewis & S. Agarwal
  Original research paper: Journal of Biological Chemistry 286
  doi:10.1074/jbc.M110.184838

  Abstract

• Dynamics of Glycoprotein Charge in the Evolutionary History of Human Influenza

  Nimalan Arinaminpathy, Bryan Grenfell & Jean-Pierre Vartanian
  Original research paper: PLoS ONE 5
  doi:10.1371/journal.pone.0015674

  Abstract

• The Pathogenic Fungus Paracoccidioides brasiliensis Exports Extracellular Vesicles Containing Highly Immunogenic  -Galactosyl Epitopes

  M. C. Vallejo et al.
  Original research paper: Eukaryotic Cell 10
  doi:10.1128/EC.00227-10

  Abstract

• Hijacking a biosynthetic pathway yields a glycosyltransferase inhibitor within cells

  Tracey M Gloster et al.
  Original research paper: Nature Chemical Biology 7 174-181 (2011)
  doi:10.1038/nchembio.520

  Abstract