Research library: browse by subject
The Research Library categorizes and provides access to all recent glycobiology-related research published by Nature Publishing Group and other journals. The selection is deliberately broad to facilitate access to all research impacting on the glycobiology community.
Glycan synthesis/glycosylation
Characterization of Helicobacter pylori Lytic Transglycosylases Slt and MltD
C. Chaput, A. Labigne & I. G. Boneca
Original research paper: Journal of Bacteriology 189
doi:10.1128/JB.01270-06Cloning of a Cholesterol- -glucosyltransferase from Helicobacter pylori
A.-H. Lebrun
Original research paper: Journal of Biological Chemistry 281
doi:10.1074/jbc.M603345200Cj1121c, a Novel UDP-4-keto-6-deoxy-GlcNAc C-4 Aminotransferase Essential for Protein Glycosylation and Virulence in Campylobacter jejuni
S. Vijayakumar
Original research paper: Journal of Biological Chemistry 281
doi:10.1074/jbc.M511714200Monocyte Differentiation Up-regulates the Expression of the Lysosomal Sialidase, Neu1, and Triggers Its Targeting to the Plasma Membrane via Major Histocompatibility Complex Class II-positive Compartments
F. Liang
Original research paper: Journal of Biological Chemistry 281
doi:10.1074/jbc.M605633200Galactosylation of IgG from rheumatoid arthritis (RA) patients – changes during therapy
Marta Pasek et al.
Original research paper: Glycoconjugate Journal 23
doi:10.1007/s10719-006-5409-0Molecular mechanisms of muscular dystrophies: old and new players
Kay E Davies & Kristen J Nowak
Original research paper: Nature Reviews Molecular Cell Biology 7 762-773 (2006)
doi:10.1038/nrm2024Advanced glycation end product (AGE) receptor 1 suppresses cell oxidant stress and activation signaling via EGF receptor
W. Cai
Original research paper: Proceedings of the National Academy of Sciences 103
doi:10.1073/pnas.0600362103Sweetening up yeast glycoprotein synthesis
Allison Doerr
Original research paper: Nature Methods 3 874
doi:10.1038/nmeth1106-874bUsing substrate engineering to harness enzymatic promiscuity and expand biological catalysis
Luke L Lairson, Andrew G Watts, Warren W Wakarchuk & Stephen G Withers
Original research paper: Nature Chemical Biology 2 724-728 (2006)
doi:10.1038/nchembio828N-Glycan structures and N-glycosylation sites of mouse soluble intercellular adhesion molecule-1 revealed by MALDI-TOF and FTICR mass spectrometry
V. I. Otto
Original research paper: Glycobiology 16
doi:10.1093/glycob/cwl032Synthesis of new analogues of salacinol containing a pendant hydroxymethyl group as potential glycosidase inhibitors
R Nasi & B Pinto
Original research paper: Carbohydrate Research 341
doi:10.1016/j.carres.2006.06.022A facile synthesis of 1,6-dideoxynojirimycin from l-sorbose
J An, X Meng, Y Yao & Z Li
Original research paper: Carbohydrate Research 341
doi:10.1016/j.carres.2006.06.002A Novel -Helix in the First Fibronectin Type III Repeat of the Neural Cell Adhesion Molecule Is Critical for N-Glycan Polysialylation
S. S. Mendiratta et al.
Original research paper: Journal of Biological Chemistry 281
doi:10.1074/jbc.M608073200Human complement factor I glycosylation: Structural and functional characterisation of the N-linked oligosaccharides
S Tsiftsoglou et al.
Original research paper: Biochimica et Biophysica Acta (BBA) - Proteins & Proteomics 1764
doi:10.1016/j.bbapap.2006.09.007Structural insights into the Notch-modifying glycosyltransferase Fringe
Martin Jinek et al.
Original research paper: Nature Structural & Molecular Biology 13 945-946 (2006)
doi:10.1038/nsmb1144Clearance mechanism of a mannosylated antibody-enzyme fusion protein used in experimental cancer therapy
H. Kogelberg et al.
Original research paper: Glycobiology 17
doi:10.1093/glycob/cwl053A sugar switch for anti-inflammatory antibodies
The finding that antibody sialylation can suppress inflammation provides new opportunities for drug development.
Roy Jefferis
Original research paper: Nature Biotechnology 24 1230-1231
doi:10.1038/nbt1006-1230N-Glycosylation of Fibroblast Growth Factor Receptor 1 Regulates Ligand and Heparan Sulfate Co-receptor Binding
L. Duchesne
Original research paper: Journal of Biological Chemistry 281
doi:10.1074/jbc.M601248200N-Glycosylation of the beta-Propeller Domain of the Integrin 5 Subunit Is Essential for 5beta1 Heterodimerization, Expression on the Cell Surface, and Its Biological Function
T. Isaji et al.
Original research paper: Journal of Biological Chemistry 281
doi:10.1074/jbc.M607771200Down-regulation of 1,4-galactosyltransferase V is a critical part of etoposide-induced apoptotic process and could be mediated by decreasing Sp1 levels in human glioma cells
J. Jiang
Original research paper: Glycobiology 16
doi:10.1093/glycob/cwl027Preferential transfer of the complete glycan is determined by the oligosaccharyltransferase complex and not by the catalytic subunit
O. Castro, F. Movsichoff & A. J. Parodi
Original research paper: Proceedings of the National Academy of Sciences 103
doi:10.1073/pnas.0607086103Structural and biochemical studies of the C-terminal domain of mouse peptide-N-glycanase identify it as a mannose-binding module
X. Zhou et al.
Original research paper: Proceedings of the National Academy of Sciences 103
doi:10.1073/pnas.0602954103N-Acetylglucosaminyltransferase III Antagonizes the Effect of N-Acetylglucosaminyltransferase V on 3beta1 Integrin-mediated Cell Migration
Y. Zhao et al.
Original research paper: Journal of Biological Chemistry 281
doi:10.1074/jbc.M607274200Fucosylation of N-Glycans Regulates the Secretion of Hepatic Glycoproteins into Bile Ducts
T. Nakagawa
Original research paper: Journal of Biological Chemistry 281
doi:10.1074/jbc.M605697200UDP-Gal: GlcNAc-R β1,4-galactosyltransferase—a target enzyme for drug design. Acceptor specificity and inhibition of the enzyme
Inka Brockhausen et al.
Original research paper: Glycoconjugate Journal 23
doi:10.1007/s10719-006-7153-xComparative characterisation of recombinant invertebrate and vertebrate peptide O-Xylosyltransferases
Andrea Brunner et al.
Original research paper: Glycoconjugate Journal 23
doi:10.1007/s10719-006-7633-zCloning and biochemical characterization of the fucanase FcnA: definition of a novel glycoside hydrolase family specific for sulfated fucans
S. Colin
Original research paper: Glycobiology 16
doi:10.1093/glycob/cwl029Procyclic Trypanosoma brucei Expresses Separate Sialidase and trans-Sialidase Enzymes on Its Surface Membrane
G. N. Montagna, J. E. Donelson & A. C. C. Frasch
Original research paper: Journal of Biological Chemistry 281
doi:10.1074/jbc.M604951200Identification of Common and Unique Peptide Substrate Preferences for the UDP-GalNAc:Polypeptide -N-acetylgalactosaminyltransferases T1 and T2 Derived from Oriented Random Peptide Substrates
T. A. Gerken, J. Raman, T. A. Fritz & O. Jamison
Original research paper: Journal of Biological Chemistry 281
doi:10.1074/jbc.M605149200Substrate Specificity Analysis of Endoplasmic Reticulum Glucosidase II Using Synthetic High Mannose-type Glycans
K. Totani, Y. Ihara, I. Matsuo & Y. Ito
Original research paper: Journal of Biological Chemistry 281
doi:10.1074/jbc.M605457200Polysialic Acid Profiles of Mice Expressing Variant Allelic Combinations of the Polysialyltransferases ST8SiaII and ST8SiaIV
S. P. Galuska et al.
Original research paper: Journal of Biological Chemistry 281
doi:10.1074/jbc.M606516200The CMP-sialic Acid Transporter Is Localized in the Medial-Trans Golgi and Possesses Two Specific Endoplasmic Reticulum Export Motifs in Its Carboxyl-terminal Cytoplasmic Tail
W. Zhao, T.-L. L. Chen, B. M. Vertel & K. J. Colley
Original research paper: Journal of Biological Chemistry 281
doi:10.1074/jbc.M605564200Roles for UDP-GlcNAc 2-Epimerase/ManNAc 6-Kinase outside of Sialic Acid Biosynthesis: MODULATION OF SIALYLTRANSFERASE AND BiP EXPRESSION, GM3 AND GD3 BIOSYNTHESIS, PROLIFERATION, AND APOPTOSIS, AND ERK1/2 PHOSPHORYLATION
Z. Wang
Original research paper: Journal of Biological Chemistry 281
doi:10.1074/jbc.M604903200Exploiting the Reversibility of Natural Product Glycosyltransferase-Catalyzed Reactions
C. Zhang
Original research paper: Science 313
doi:10.1126/science.1130028Modification of p53 with O-linked N-acetylglucosamine regulates p53 activity and stability
Won Ho Yang et al.
Original research paper: Nature Cell Biology 8 1074-1083 (2006)
doi:10.1038/ncb1470Differentiation elicits negative regulation of human β-galactoside α2,6-sialyltransferase at the mRNA level in the HL-60 cell line
A Taniguchi
Original research paper: FEBS Letters 441
doi:10.1016/S0014-5793(98)01548-8Arraying glycomics: a novel bi-functional spacer for one-step microscale derivatization of free reducing glycans
O. Bohorov, H. Andersson-sand, J. Hoffmann & O. Blixt
Original research paper: Glycobiology 16
doi:10.1093/glycob/cwl044Identification of core 1 O-glycan T-synthase from Caenorhabditis elegans
T. Ju
Original research paper: Glycobiology 16
doi:10.1093/glycob/cwl008Isomer and glycomer complexities of core GlcNAcs in Caenorhabditis elegans
A. J. Hanneman
Original research paper: Glycobiology 16
doi:10.1093/glycob/cwl011A Mutant Chaperone Converts a Wild-Type Protein into a Tumor-Specific Antigen
A. Schietinger et al.
Original research paper: Science 314
doi:10.1126/science.1129200Thrombocytopenia and kidney disease in mice with a mutation in the C1galt1 gene
W. S. Alexander et al.
Original research paper: Proceedings of the National Academy of Sciences 103
doi:10.1073/pnas.0607872103High-throughput screening methodology for the directed evolution of glycosyltransferases
Amir Aharoni et al.
Original research paper: Nature Methods 3 609-614 (2006)
doi:10.1038/nmeth899The charged sialic acid exhibits its power again: a new high-throughput screening technology
In this issue, the Withers laboratory takes advantage of the negatively charged sialic acid to develop a high-throughput screening technology that can be used for evolving glycosyltransferases with new enzymatic activities.
Peng George Wang
Original research paper: Nature Methods 3 589-590
doi:10.1038/nmeth0806-589Glycopeptides as versatile tools for glycobiology
T. Buskas
Original research paper: Glycobiology 16
doi:10.1093/glycob/cwj125Construction of a Library of Human Glycosyltransferases Immobilized in the Cell Wall of Saccharomyces cerevisiae
Y.-i. Shimma, F. Saito, F. Oosawa & Y. Jigami
Original research paper: Applied and Environmental Microbiology 72
doi:10.1128/AEM.01378-06Insights in the glycosylation steps during biosynthesis of the antitumor anthracycline cosmomycin: characterization of two glycosyltransferase genes
Leandro M. Garrido et al.
Original research paper: Applied Microbiology and Biotechnology 73
doi:10.1007/s00253-006-0453-zGlycan analysis of monoclonal antibodies secreted in deposition disorders indicates that subsets of plasma cells differentially process IgG glycans
Lone A. Omtvedt et al.
Original research paper: Arthritis & Rheumatism 54
doi:10.1002/art.22171Molecular interaction between fukutin and POMGnT1 in the glycosylation pathway of α-dystroglycan
H Xiong et al.
Original research paper: Biochemical and Biophysical Research Communications 350
doi:10.1016/j.bbrc.2006.09.129Structural analyses of O-glycan sugar chains on IgA1 hinge region using SELDI-TOFMS with various lectins
K Takahashi et al.
Original research paper: Biochemical and Biophysical Research Communications 350
doi:10.1016/j.bbrc.2006.09.075Expression cloning of cholesterol α-glucosyltransferase, a unique enzyme that can be inhibited by natural antibiotic gastric mucin O-glycans, from Helicobacter pylori
H Lee et al.
Original research paper: Biochemical and Biophysical Research Communications 349
doi:10.1016/j.bbrc.2006.08.145Man2C1, an α-mannosidase, is involved in the trimming of free oligosaccharides in the cytosol
Tadashi Suzuki et al.
Original research paper: Biochemical Journal 400
doi:10.1042/BJ20060945K.A. Nishina et al.
Original research paper: Biochemistry 45
doi:10.1021/bi061526kAltered granulopoietic profile and exaggerated acute neutrophilic inflammation in mice with targeted deficiency in the sialyltransferase ST6Gal I
M. Nasirikenari et al.
Original research paper: Blood 108
doi:10.1182/blood-2006-04-014779Identification of a novel glycosyltransferase involved in LOS biosynthesis of Moraxella catarrhalis
J Wilson et al.
Original research paper: Carbohydrate Research 341
doi:10.1016/j.carres.2006.07.009Measurement of Fibrosis Marker Xylosyltransferase I Activity by HPLC Electrospray Ionization Tandem Mass Spectrometry
J. Kuhn et al.
Original research paper: Clinical Chemistry 52
doi:10.1373/clinchem.2006.071167A Thermostable Î
-Galactosidase from Lactobacillus fermentum CRL722: Genetic Characterization and Main PropertiesE. A. Carrera-silva et al.
Original research paper: Current Microbiology 53
doi:10.1007/s00284-005-0442-yÎ
2,3-Sialyltransferase-IV is essential for L-selectin ligand function in inflammationMarkus Sperandio et al.
Original research paper: European Journal of Immunology 36
doi:10.1002/eji.200636157N-linked glycosylation of IL-13R 2 is essential for optimal IL-13 inhibitory activity
M. Kioi, S. Seetharam & R. K. Puri
Original research paper: The FASEB Journal 20
doi:10.1096/fj.06-5995fjeSaccharomyces cerevisiae?1,6-mannosyltransferase has a catalytic potential to transfer a second mannose molecule
Toshihiko Kitajima, Yasunori Chiba & Yoshifumi Jigami
Original research paper: FEBS Journal 273
doi:10.1111/j.1742-4658.2006.05505.xThe collapsin response mediator protein 1 (CRMP-1) and the promyelocytic leukemia zinc finger protein (PLZF) bind to UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (GNE), the key enzyme of sialic acid biosynthesis
W Weidemann et al.
Original research paper: FEBS Letters 580
doi:10.1016/j.febslet.2006.11.015Interleukin-1β induces sialyl Lewis X on hepatocellular carcinoma HuH-7 cells via enhanced expression of ST3Gal IV and FUT VI gene
K Higai, N Miyazaki, Y Azuma & K Matsumoto
Original research paper: FEBS Letters 580
doi:10.1016/j.febslet.2006.09.073Fucosylation in prokaryotes and eukaryotes
B. Ma, J. L. Simala-grant & D. E. Taylor
Original research paper: Glycobiology 16
doi:10.1093/glycob/cwl040Effects of N-glycan processing inhibitors on signaling events and induction of apoptosis in galectin-1-stimulated Jurkat T lymphocytes
H. Walzel et al.
Original research paper: Glycobiology 16
doi:10.1093/glycob/cwl037Molecular cloning and characterization of a novel human 1,3-glucosyltransferase, which is localized at the endoplasmic reticulum and glucosylates O-linked fucosylglycan on thrombospondin type 1 repeat domain
T. Sato et al.
Original research paper: Glycobiology 16
doi:10.1093/glycob/cwl035O-Glycosylation of Serum IgA1 Antibodies against Mucosal and Systemic Antigens in IgA Nephropathy
A. C. Smith, K. Molyneux, J. Feehally & J. Barratt
Original research paper: Journal of the American Society of Nephrology 17
doi:10.1681/ASN.2006060658Differential Glycosylation of Polymeric and Monomeric IgA: A Possible Role in Glomerular Inflammation in IgA Nephropathy
B. D. Oortwijn et al.
Original research paper: Journal of the American Society of Nephrology 17
doi:10.1681/ASN.2006040388Mutational Analysis of the Medicago Glycosyltransferase UGT71G1 Reveals Residues That Control Regioselectivity for (Iso)flavonoid Glycosylation
X.-Z. He, X. Wang & R. A. Dixon
Original research paper: Journal of Biological Chemistry 281
doi:10.1074/jbc.M605767200Two Xyloglucan Xylosyltransferases Catalyze the Addition of Multiple Xylosyl Residues to Cellohexaose
D. M. Cavalier & K. Keegstra
Original research paper: Journal of Biological Chemistry 281
doi:10.1074/jbc.M606379200N-glycan processing in ER quality control
L. W. Ruddock & M. Molinari
Original research paper: Journal of Cell Science 119
doi:10.1242/jcs.03225Q. Yang et al.
Original research paper: Langmuir 22
doi:10.1021/la061986eTransition of Galactosyltransferase 1 from Trans-Golgi Cisterna to the Trans-Golgi Network Is Signal Mediated
B. E. Schaub, B. Berger, E. G. Berger & J. Rohrer
Original research paper: Molecular Biology of the Cell 17
doi:10.1091/mbc.E06-08-0665A Eukaryotic Capsular Polysaccharide Is Synthesized Intracellularly and Secreted via Exocytosis
A. Yoneda & T. L. Doering
Original research paper: Molecular Biology of the Cell 17
doi:10.1091/mbc.E06-08-0701All-or-none N-glycosylation in primate follicle-stimulating hormone β-subunits
G Bousfield et al.
Original research paper: Molecular and Cellular Endocrinology 260-262
doi:10.1016/j.mce.2006.02.017Unusual N-Glycan Structures in -Mannosidase II/IIx Double Null Embryos Identified by a Systematic Glycomics Approach Based on Two-dimensional LC Mapping and Matrix-dependent Selective Fragmentation Method in MALDI-TOF/TOF Mass Spectrometry
M. Hato et al.
Original research paper: Molecular & Cellular Proteomics 5
doi:10.1074/mcp.M600213-MCP200Intracellular binding of fukutin and α-dystroglycan: Relation to glycosylation of α-dystroglycan
T Yamamoto et al.
Original research paper: Neuroscience Research 56
doi:10.1016/j.neures.2006.08.009Oligomannoside mimetics by glycosylation of ?octopus glycosides? and their investigation as inhibitors of type 1 fimbriae-mediated adhesion of Escherichia coli
Michael Dubber, Oliver Sperling & Thisbe K. Lindhorst
Original research paper: Organic & Biomolecular Chemistry 4
doi:10.1039/b610741aArabidopsis Reversibly Glycosylated Polypeptides 1 and 2 Are Essential for Pollen Development
G. Drakakaki et al.
Original research paper: PLANT PHYSIOLOGY 142
doi:10.1104/pp.106.086363N-Linked Glycosylation of Folded Proteins by the Bacterial Oligosaccharyltransferase
M. Kowarik et al.
Original research paper: Science 314
doi:10.1126/science.1134351