Functional Glycomics homepage
ORGANIZATION OF THE SUBGROUPS



Major objective: To facilitate communications among investigators with similar interests under the broad scope of the CFG.

The following ten subgroups established in representing the range of the research and the relevance to the Consortium's specific aims.

To self assign to these sub-groups click here - you will need your login name and password (if you have forgotten your password, please ask Anna annacrie@scripps.edu).

Subgroup Leader's
Name		 Topics Glycan binding protein
1. Microorganism recognition of host glycans
    Gillian Air
  • Virus receptors
  • Bacterial host cell receptors
  • Fungal receptors
  • Protozoan receptors
  • Glycan binding attachment proteins of pathogenenic and commensal organisms
2. Immune recognition of glycans
    Yvette Van Kooyk
  • Innate immune recognition of glycans on bacteria, viruses, yeasts etc. by host cell glycan binding proteins
  • Links between innate and adaptive immunity
  • Glycan-based autoantigens
  • Carbohydrate vaccines
  • C-type lectins
  • Siglecs
  • Galectins
  • CD1 recognition of glycolipids
  • Glycan specific antibodies
3. Glycans in immune cell communication
    Paul Crocker
  • Glycan-mediated trafficking of leukocytes
  • Regulation of cell signaling receptors
  • Regulation of cell fate during differentiation
  • Selectins (C-type lectins)
  • Siglecs (regulation of receptors signaling
  • Galectins
4. Glycans in development and physiology
    John Hanover
  • Glycans mediating cell-cell interactions during development
  • Glycans as morphogen gradients (e.g. proteoglycans)
  • Glycoprotein clearance
  • Siglecs (MAG)
  • Glycolipids in glycan-protein and glycan-glycan interactions
  • C-type lectins
5. Glycans in cancer biology
    Joyce Taylor-Papadimitriou
  • Non-antigen roles of glycans in cancer cell biology
  • Proteoglycans and cancer
  • Selectins and metastasis of cancer cells
  • MUCs in cancer
  • Glycan-based cancer biomarkers
  • C-type lectins
  • Glycan specific antibodies
  • Siglecs
  • Galectins
6. Glycans in protein conformation and function
    James Prestegard
  • Glycans in protein folding
  • Glycans in modulating protein conformation (e.g. IgG-Fc domain, Glut-2 N-glycan branching)
  • Functional impact of glycans on glycoproteins
  • L-type lectins, F-type lectins, Calnexin-calreticulin
7. Analytical glycomics
    Michael Tiemeyer
  • Glycomic profiling of N- and O-linked glycans and glycolipids
  • All
8. Chemical synthesis and glycan microarrays
    M.G. Finn
  • Synthesis of glycan ligands for glycan binding proteins
  • Glycan microarrays
  • All
9. 3-D Structural glycobiology
    Robert Woods
  • Methods for determining 3D structures of glycans
  • Analysis of molecular interactions of glycan binding proteins and their ligands
  • Predictions of molecular interactions of glycan binding proteins and their ligands
  • All
10. Bioinformatics
    William York
  • Database development
  • Novel applications involving data mining
  • All


Last Updated Thursday, 17-Jul-2008 13:37:57 EDT. Please contact us with comments/questions.