| Subgroup |
Leader's
Name |
Topics |
|
1. Glycans in microbe-host interactions
|
Christine Szymanski
|
- Virus receptors
- Bacterial host cell receptors
- Fungal receptors
- Protozoan receptors
|
|
2. Glycans in immune recognition and function
|
Brian Cobb
|
- Innate immune recognition of glycans on bacteria, viruses, yeasts etc. by host cell glycan binding proteins
- Links between innate and adaptive immunity
- Glycan-based autoantigens
- Carbohydrate vaccines
- Glycan-mediated trafficking of leukocytes
- Regulation of cell signaling receptors
- Regulation of cell fate during differentiation
|
|
3. Glycans in cancer biology
|
J Michael Pierce
|
- Non-antigen roles of glycans in cancer cell biology
- Proteoglycans and cancer
- Selectins and metastasis of cancer cells
- MUCs in cancer
- Glycan-based cancer biomarkers
|
|
4. Glycans in development and physiology
|
John Hanover
|
- Glycans mediating cell-cell interactions during development
- Glycans as morphogen gradients (e.g. proteoglycans)
- Glycoprotein clearance
|
|
5. Structural glycobiology
|
Anne Imberty
|
- Glycans in protein folding
- Glycans in modulating protein conformation (e.g. IgG-Fc domain, Glut-2 N-glycan branching)
- Methods for determining 3D structures of glycans
- Analysis of molecular interactions of glycan binding proteins and their ligands
- Predictions of molecular interactions of glycan binding proteins and their ligands
|
|
6. Glycan synthesis and microarrays
|
Geert-Jan Boons
|
- Synthesis of glycan ligands for glycan binding proteins
- Glycan microarrays
|
|
7. Glycomics and Glycoinformatics
|
Stuart Haslam
|
- Glycomic profiling of N- and O-linked glycans and glycolipids
- Database development
- Novel applications involving data mining
|
