This Core is determining the phenotype of selected knockout mouse strains. Some strains have been contributed by Participating Investigators and selected by the Steering Committee for their relevance to the CFG. Other novel knockout mouse strains are produced by the Mouse Transgenics Core (F) and are being scheduled for phenotyping with priority status. Standard tests and assays are conducted by three Subcores in the areas of hematology, histology, and immune function. The assays include histologic assessment of organ structure, as well as function of the liver, heart, lung, vasculature, kidneys, and blood cell production, coagulation and homeostasis. The development and function of the innate and acquired immune systems are also studied. Data are being deposited in the Central Database. These studies are providing essential information for pursuing the program’s Specific Aims toward defining the functions of glycan-binding proteins (GBPs), glycosyltransferases (GTs), and GBP-ligand relationships.
This Core offers the service of phenotype characterization of mice in the public domain. Phenotype characterization will include hematology, coagulation, serum chemistry, static and induced immune responses and histology. Behavior experiments are no longer being performed. Click here for more information about Core G’s phenotype analysis service.
Specific Objectives
Phenotype mice bearing altered GBP and GT genes
Breed and supply mice for the Immunology and Metabolism/Behavior Sub-Cores
