REAGENT BANK
CARBOHYDRATE COMPOUNDS,
GLYCAN-BINDING PROTEINS & ANTIBODIES
The Glycan Array Synthesis Core (D) produces carbohydrate compounds, glycan-binding proteins, and antibodies for the CFG Reagent Bank. Investigators use these reagents in studies that help achieve the CFG's overall goal to "define paradigms by which protein-carbohydrate interactions mediate cell communication".
The following compounds and proteins are currently available for distribution to investigators, and the quality control data for these reagents can be viewed by clicking to methods and data.
Synthetic Glycans are available for investigators to confirm ligands identified by glycan array screening at the Protein-Glycan Interaction Core (H), further assess lectin-ligand specificity and affinity, inhibit protein-glycan interactions, perform co-crystallization studies, etc.
Glycan-binding proteins and antibodies are available for investigators to identify and/or purify glycoconjugates, inhibit protein-glycan interactions, define the glycosylation status of cells, perform histochemical staining, assay enzymes, sort cells, etc.
Carbohydrate standards for mass spectrometry are available for investigators in need of complex glycans of known structure. The library includes glycans with both modified and un-modified reducing ends.
These reagents are generated to:
- Define the specificity and affinity for carbohydrate ligands
- Establish the cell types involved in communication
- Identify the ligand(s) that mediate glycan-binding protein (GBP) binding
- Determine how GBP-ligand interactions mediate cell communication
Enzymes
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Compounds for the next version of the Mammalian Glycan Array
Pathogen Glycan Array
More Information
Methods and Data
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