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MOUSE LINES


Novel Strains Generated by Core F


The table below (sorted by Gene Family) lists knockout mouse lines that have been created by the Mouse Transgenics Core (F) and are currently available for distribution. Knockout mouse lines that will soon be available from Core F are also listed. Each of these glycogene targets were specifically chosen by the Mouse Committee and approved by the Steering Committee for their impact on the's CFG overall goal. To view the rationale for each target, click here.

Two or three breeding pairs of homozygous null animals can be provided to investigators upon Steering Committee approval. To obtain knockout mice, please submit a resource request.

Twenty-nine knockout strains acquired from Participating Investigators that have been available through Core F are in transition to new homes. When the transition is complete, some strains will be available from The Jackson Laboratories and some will continue to be available from the original contributors. During the transition phase they will continue to be available from Core F. Please contact the Director of Core F, Dr. Bo Ma, if you are interested in obtaining any of these strains. He will let you know the strain’s status and suggest the appropriate contact.

Targeted Gene Colony Code Name1 Gene Symbol2 Gene Family Status
Name of Enzyme or Protein
Dcir DR-D3 Clec4a2 GBP: C-type Available Dendritic cell immunoreceptor
Dcsign DC-D3,4 Cd209a GBP: C-type Available Dendritic Cell-specific ICAM Grabbing Nonintegrin
Langerin LA-D3. 4 Cd207 GBP: C-type Available Langerhans cell-specific C-type lectin/KO created at CFG
Mcl MC-D3 Clec4d GBP: C-type Available Macrophage C-type lectin
Mincle MN-D3 Clec4e GBP: C-type Available Calcium-dependent carbohydrate recognition domain lectin
Signr1 SB-D3 Cd209b GBP: C-type Available Dendritic Cell-specific ICAM Grabbing Nonintegrin 1
Signr3 SD-D3 Cd209d GBP: C-type Available Dendritic Cell-specific ICAM Grabbing Nonintegrin 3
Galectin2 GX-D3,4 Lgals2 GBP: Galectin Available Lectin, galactose-binding, soluble 2
Galectin9 GJ6 Lgals9 GBP: Galectin Available Lectin, galactose binding, soluble 9
Galectin9 GK-D3, 4 Lgals9 GBP: Galectin Available soon Lectin, galactose binding, soluble 9
Galectin1 & Galectin9 GB7 Lgals1 and Lgals9 GBP: Galectin Available soon Galectin1 & Galectin9 double KO
SiglecH SH-F8 Siglech GBP: Siglec Available soon Sialic acid-binding Ig-like lectin H
SiglecH SH-D3 Siglech GBP: Siglec Available soon Sialic acid-binding Ig-like lectin H
B3gnT5 BE-F8 B3gnt5 GT Available soon UDP-GlcNAc:bGalb1,3-N-acetylglucosaminyltransferase 5
B3gnT5 BE-D3 B3gnt5 GT Available soon UDP-GlcNAc:bGalb1,3-N-acetylglucosaminyltransferase 5
Galnact3 TC-F8 Galnt3 GT Available Soon UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 3
Galnact3 TC-D8 Galnt3 GT Available Soon UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 3
Glcnac T9 MB-F8 Mgat5b GT Available Mannoside acetylglucosaminyltransferase 5, isoenzyme B
Glcnac T9 MB-D3 Mgat5b GT Available Mannoside acetylglucosaminyltransferase 5, isoenzyme B
LSECtin CG-F8 Clec4g GT Available Soon C-type lectin domain family 4, member g
LSECtin CG-D8 Clec4g GT Available Soon C-type lectin domain family 4, member g
Manic Fringe MF-F8 Mfng GT Available MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
Manic Fringe MF-D3 Mfng GT Available soon MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
Pomgnt1 PM-F8 Pomgnt1 GT Available protein O-linked mannose beta1,2-N-acetylglucosaminyltransferase
Pomgnt1 PM-D3 Pomgnt1 GT Available soon protein O-linked mannose beta1,2-N-acetylglucosaminyltransferase
St6GalNAc II SS-F8 St6galnac2 GT Available ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
St6GalNAc II SS-D3 St6galnac2 GT Available ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
Galgt1 & Galgt2 GD7 Galgt1 and Galgt2 GT: GalNAc Available GM2/GD2 Synthase & GalNAcT Sda blood group double KO

1 CFG internal mouse line identifier, specific and unique for each construct, background and type of mutation.

2 As per the Mouse Genomic Nomenclature Committee (MGNC) maintained by Mouse Genome Informatics (MGI) of The Jackson Laboratory.

3 D - Delta Allele.

4 An alternative line where the replacement neo cassette has been removed from the targeted locus.

5 N - contains neo cassette.

6 This line obtained from Lexicon Genetics, Inc, requires signing a separate agreement with Lexicon Genetics Inc., creators and owners of the line.

7 A previously unavailable double knockout strain created at Core F by interbreeding.

8 F-Floxed Allele.





PI Inputs/Suggestions

Request Mouse Lines

Timeline for Generating Mouse Lines

Novel strains available from MMRRC

Additional Published Knockout Strains

More Information


Last Updated Tuesday, 16-Jun-2009 13:26:10 EDT. Please contact us with comments/questions.