MOUSE LINES
Status of Generating Mouse Lines
Completed Vector Designs
The following mouse lines (sorted by Gene Family) are being generated by the Mouse transgenics Core (F). The dates of completion of each step are indicated. 'Completed' Vector Design entries link to a description of the vector design. The new lines are being generated in a C57BL6 background. Embryonal stem cell line Bruce 4 (for reference click here) and isogenic B6 BAC DNA are being used.
| Targeted Gene | Colony Code Name1 | Gene Symbol2 | Vector Type | Create Vector | Isolate primary ES Clones3 | Isolate cre-modified ES clones | Confirm ES clones | Generate Chimeric Mice | Coat Color Trans- mission |
Select Hetero- zygous Mice |
Breed Homo- zygous Mice |
Gene Family | |
| Clec-2 | CL | Clec1b | C-Type lectin domain family 1, member b |
Conditional | May 2008 |
in progress |
GBP: C-Type | ||||||
| Clec-2 & Clec-9A | CN | Clec9a | C-Type lectin domain family 1, member b family 9, member a |
Replacement | May 2008 |
in progress |
GBP: C-Type | ||||||
| Clec5a | CF | Clec5a | GBP: C-Type lectin domain family 5, member a |
Conditional | Oct 2008 |
in progress |
GBP: C-Type | ||||||
| Dcar | DA | Clec4b | Dendritic cell activating immuoreceptor | Conditional | Oct 2007 |
in progress |
GBP: C-Type | ||||||
| Dcir | DR | Clec4a2 | Dendritic Cell Immuno Receptor | Conditional | Jul 2003 |
Jun 2004 |
Oct 2004 |
Nov 2004 |
Jan 2005 |
May 2005 |
Jun 2005 |
Feb 2006 |
GBP: C-Type |
| Dcsign | DC | Cd209a | Dendritic Cell Specific ICAM Grabbing Nonintegrin |
Replacement | Mar 2003 |
Jul 2003 |
N/A | Feb 2003 |
Mar 2004 |
Nov 2005 |
Dec 2005 |
Sept 2006 |
GBP: C-Type |
| Dectin2 | DT | Clec4n | Calcium dependent, carbohydrate recognition domain lectin |
Conditional | in progress |
GBP: C-Type | |||||||
| Langerin | LA | Cd207 | Langerhans cell specific GBP: C-Type lectin |
Replacement | Dec 2002 |
Mar 2003 |
N/A | Mar 2003 |
Jan 2008 |
GBP: C-Type | |||
| MBL-C | ML | Mbl2 | mannose binding lectin (C) | Conditional | June 2007 4 |
in progress |
GBP: C-Type | ||||||
| Mcl | MC | Clec4d | Calcium dependent, carbohydrate recognition domain lectin |
Conditional | Nov 2003 |
Jan 2004 |
May 2004 |
Feb 2004 |
Mar 2004 |
Aug 2004 |
Sep 2004 |
Jan 2005 |
GBP: C-Type |
| Mgl1 +Mgl2 | MD | macrophage galactose N-acetyl-galactosamine specific lectin 1 and 2 |
Replacement | May 2008 |
in progress |
GBP: C-Type | |||||||
| Mgl2 | MT | Mgl2 | macrophage galactose N-acetyl-galactosamine specific lectin 2 |
Conditional | May 2008 |
GBP: C-Type | |||||||
| Mincle | MN | Clec4e | Calcium dependent, carbohydrate recognition domain lectin |
Conditional | Mar 2003 |
Aug 2004 |
Aug 2003 |
Oct 2004 |
Dec 2004 |
Feb 2005 |
Mar 2005 |
May 2005 |
GBP: C-Type |
| Scavenger Receptor | SR | Colec12 | Collectin sub-family member 12, scavenger receptor GBP: C-Type lectin |
Conditional | in progress |
GBP: C-Type | |||||||
| Signr1 | SB | Cd209b | Dendritic Cell Specific ICAM Grabbing Nonintegrin Related 1 |
Conditional | Jun 2003 |
Jun 2004 |
Jul 2004 |
Jul 2004 |
Jul 2004 |
Feb 2006 |
Mar 2006 |
Dec 2006 |
GBP: C-Type |
| Signr3 | SD | CD209d | Dendritic Cell Specific ICAM Grabbing Nonintegrin Related 3 |
Conditional | Oct 2003 |
Feb 2004 |
May 2004 |
Apr 2004 |
Oct 2004 |
Jan 2006 |
Mar 2006 |
Jan 2007 |
GBP: C-Type |
| Signr7 | RG | cd209g | CD209g antigen | Replacement | in progress |
GBP: C-Type | |||||||
| LECtin | CG | Clec4g | Liver Sinusoidal Endothelial Cell lectin | Conditional | Aug 2007 |
in progress |
GBP: C-Type | ||||||
| Galectin2 | GX | Lgals2 | Lectin, galactose- binding, soluble 2 |
Replacement | Dec 2006 |
Feb 2007 |
N/A | May 2007 |
May 2007 |
Aug 2007 |
Aug 2007 |
in progress |
GBP: Galectin |
| Galectin4 | GE | Lgals4 | Lectin, galactose- binding, soluble 4 |
Conditional | Oct 2007 |
in progress |
GBP: Galectin | ||||||
| Galectin8 | GH | Lgals8 | Lectin, galactose- binding, soluble 8 |
Replacement | Apr 2005 |
suspended | Available from MMRRC |
GBP: Galectin | |||||
| Galectin9- Imported |
GJ | Lgals9 | Lectin, galactose- binding, soluble 9 |
Insertion | N/A | N/A | N/A | N/A | N/A | N/A | May 2003 | Aug 2003 | GBP: Galectin |
| Galectin 9 (B4) | GK | Lgals9 | Lectin, galactose- binding, soluble 9 |
Replacement | Jan 2007 |
Aug 2007 |
N/A | Sept 2007 |
Oct 2007 |
in progress |
GBP: Galectin | ||
| Siglech | SH | Siglech | Sialic acid-binding immunoglobulin-like lectin H |
Conditional | Apr 2007 |
Aug 2007 |
N/A | Aug 2007 |
Oct 2007 |
in progress |
GBP: Siglec | ||
| Siglec 15 | SI | Siglec 15 | Sialic acid binding Ig-like lectin 15 |
Conditional | in progress |
GBP: Siglec | |||||||
| B3gnt4 | LF | B3gnt4 | b1,3-N-acetyl glycosaminyltransferase 4 |
Conditional | Oct 2007 |
in progress |
GT | ||||||
| B3gnT5 | BE | B3gnt5 | UDP-GlcNAc:bGalb1,3-N-acetylglucosaminyltransferase 5 | Conditional | Nov 2007 |
Mar 2008 |
N/A | May 2008 |
May 2008 |
in progress |
GT | ||
| B3gnT8 | BH | B3gnt8 | UDP-GlcNAc:bGalb1,3-N-acetylglucosaminyltransferase 8 | Conditional | Nov 2007 |
in progress | GT | ||||||
| GalNAc4ST-1 | GL | Chst8 | carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8 | Conditional | in progress |
GT | |||||||
| GalNAc4ST-2 | GS | Chst9 | carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 9 | Conditional | in progress |
GT | |||||||
| Galnact3 | TC | Galnt3 | UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyl transferase 3 |
Conditional | Oct 2006 |
in progress |
GT | ||||||
| Glcnact6 | MH | Mgat4c | Mannosyl a1,3-glycoprotein b1,4-N-acetylglucosaminyl transferase, isozyme C (putative) |
Conditional | in progress |
GT | |||||||
| Glcnact9 | MB | Mgat5b | Mannoside acetylglucosaminyl transferase 5, isoenzyme B |
Replacement | May 2006 |
Nov 2006 |
in progress |
GT | |||||
| KSGal6ST-1 | KS | Chst1 | carbohydrate (keratan sulfate Gal-6) sulfotransferase 1 | Replacement | Apr 2007 |
Aug 2007 |
N/A | Oct 2007 |
Jan 2008 |
in progress |
GT | ||
| Kuppfer Cell Receptor | KR | Clec4f | C-type lectin domain family 4, member f | Conditional | in progress |
GT | |||||||
| Manic Fringe | MF | MFNG | Manic fringe homolog (Drosophila) |
Conditional | Dec 2006 |
June 2007 |
Nov 2007 |
Jan 2008 |
May 2008 |
in progress |
GT | ||
| Pomgnt1 | PM | Pomgnt1 | O-mannosyl b1,2 N-acetyl glucosaminyl transferase 1 |
Conditional | May 2004 |
Aug 2005 |
Feb 2006 |
Feb 2006 |
Oct 2007 |
in progress |
GT | ||
| ppGalNAc T12 | TT | Galnt12 | UDP-N-acetyl-alpha-D-galactosamine: polypeptide N-acetylgalactosaminyltransferase 12 | Conditional | in progress |
GT | |||||||
| St6galnac1 | SM | St6 galnac1 |
ST6 (a-N-acetyl-neuraminyl -2,3-b-galactosyl-1,3)N-acetyl galactosaminide a-2,6-sialyl transferase 1 |
Conditional | in progress |
GT | |||||||
| St6galnac2 | SS | St6 galnac2 |
ST6 (a-N-acetyl-neuraminyl -2,3-b-galactosyl-1,3)N-acetyl galactosaminide a-2,6-sialyl transferase 2 |
Conditional | N/A | 129 R1 | June 2007 5 |
Sept 2007 |
Oct 2007 |
Jan 2008 |
Mar 2008 |
in progress |
GT |
| St6galnac4 | SK | St6 galnac4 |
ST6 (a-N-acetyl-neuraminyl -2,3-b-galactosyl-1,3)N-acetyl galactosaminide a-2,6-sialyl transferase 4 |
Replacement | Feb 2007 |
Aug 2007 |
N/A | Aug 2007 |
Jan 2008 |
in progress |
GT | ||
| St8sia6 | SN | St8sia6 | ST8 a-N-acetyl-neuraminide a-2,8-sialyl transferase 6 | Conditional | Dec 2006 |
in progress |
GT | ||||||
|
1 CFG internal mouse line identifier, specific and unique for each construct, background and type of mutation 2 As per the Mouse Genomic Nomenclature Committee (MGNC) maintained by Mouse Genome Informatics (MGI) of The Jackson Laboratory 3 ES lines: C2 = CMTII (Specialty Media); B4 = Bruce 4 4 DNA construct provided by Dr. Jamey Marth 5 ES cell clones provided by Dr. Jamey Marth N/A, not applicable | |||||||||||||
PI Inputs/Suggestions
Request Mouse Lines
Novel Strains Available from Core F
Novel Strains Available from MMRRC
Additional Published Knockout Strains
More Information