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Compounds scheduled for synthesis by Glycan Array Synthesis Core D

The CFG glycan compound library and glycan microarray represent a unique resource that is filling a major gap in information on the specificities of Glycan-Binding Protein (GBP)s. Expanding the glycan library is a major priority of the Glycan Array Synthesis Core D. To this end, the following new glycans are scheduled for synthesis by the Glycan array Synthesis Core D. Following synthesis the glycans will be added to the CFG Glycan Array. Glycans produced in sufficient quantities will be made available in the CFG Reagent Bank (* 5 to 50 microgram as MS standards). The table below is sorted by glycan type.

Glycan Type Compound Name Common Name Glycan
Array		 Reagent
Bank
Ganglioside Galb1-3GalNAcb1-4(NeuAca2-8NeuAca2-8NeuAca2-3)Galb1-4Glcb-sp GT1C *
Ganglioside GalNAcb1-4Galb1-4Glcb-sp AsialoGM1 X *
Ganglioside NeuAca2-3Galb1-3GalNAcb1-4(NeuAca2-8NeuAca2-8NeuAca2-3)Galb1-4Glcb-sp GQ1C *
Ganglioside Neu5Aca2-3GalNAcb1-4Galb1-4Glcb-sp GM1b X *
Ganglioside (NeuAca2-8NeuAca2-3)Galb1-3GalNAcb1-4(NeuAca2-8NeuAca2-3)Galb1-4Glcb-sp GQ1b X *
N-Glycan Fuca1-2Galb1-4GlcNAcb1-4(Fuca1-2Galb1-4GlcNAcb1-2)Mana1-3(Fuca1-2Galb1-4GlcNAcb1-2Mana1-6)Manb1-4GlcNAcb1-4GlcNAc-N Tri-H type-Asp *
N-Glycan Gala1-3(Fuca1-2)Galb1-3GlcNAcb1-2Mana1-3(Gala1-3(Fuca1-2)Galb1-3GlcNAcb1-2Mana1-6)Manb1-4GlcNAcb1-4(Fuca1-6)GlcNAcb-NST Bi-Btype 1, core fuc *
N-Glycan Gala1-3(Fuca1-2)Galb1-4GlcNAcb1-2Mana1-3(Gala1-3(Fuca1-2)Galb1-4GlcNAcb1-2Mana1-6)Manb1-4GlcNAcb1-4(Fuca1-6)GlcNAcb-NST Bi-Btype 2 *
N-Glycan Galb1-3GlcNAcb1-2Mana1-3(GlcNAcb1-4)(Galb1-3GlcNAcb1-2Mana1-6)Manb1-4GlcNAcb1-4GlcNAcb-sp 3'NA2B-sp *
N-Glycan Galb1-4GlcNAcb1-2Mana1-3(Galb1-4GlcNAcb1-2)(Galb1-4GlcNAcb1-6)Mana1-6)Manb1-4GlcNAcb1-4GlcNAcb-NK 4'NA3(b1-6) *
N-Glycan GalNAca1-3(Fuca1-2)Galb1-4GlcNAcb1-2Mana1-3[GalNAca1-3(Fuca1-2)Galb1-4GlcNAcb1-2Mana1-6]Manb1-4GlcNAcb1-4(Fuca1-6)GlcNAc-NST Bi-A type 2-core Fuc X *
N-Glycan GlcNAca1-4Galb1-4GlcNAcb1-2Mana1-6(GlcNAca1-4Galb1-4GlcNAcb1-2Mana1-3)Manb1-4GlcNAcb1-4GlcNAc-pp (Bi) GlcNAca1-4 type 2 X
N-Glycan Neu5Aca2-3Galb1-4(Fuca1-3)GlcNAcb1-2Mana1-6[Neu5Aca2-3Galb1-4(Fuca1-3)GlcNAcb1-2Mana1-3]Manb1-4GlcNAcb1-4GlcNAc-pp Bi-SLeX X *
N-Glycan Neu5Aca2-3Galb1-4GlcNAcb1-2Mana1-3(GlcNAcb1-4)(Neu5Aca2-3Galb1-4GlcNAcb1-2Mana1-6)Manb1-4GlcNAcb1-4GlcNAcb-sp 3'A2B-sp *
N-Glycan Neu5Aca2-3Galb1-4GlcNAcb1-4(Neu5Aca2-3Galb1-4GlcNAcb1-2)Mana1-3(GlcNAcb1-4)(Neu5Aca2-3Galb1-4GlcNAcb1-2Mana1-6)Manb1-4GlcNAcb1-4GlcNAcb-sp 3'A3B(1-4)-sp *
N-Glycan Neu5Aca2-3Galb1-4GlcNAcb1-2Mana1-3(GlcNAcb1-4)(Neu5Aca2-3Galb1-4GlcNAcb1-6[Neu5Aca2-3Galb1-4GlcNAcb1-2)Mana1-6]Manb1-4GlcNAcb1-4GlcNAcb-sp 3'A3B(1-6)-sp *
N-Glycan Neu5Aca2-3Galb1-4GlcNAcb1-4(Neu5Aca2-3Galb1-4GlcNAcb1-2)Mana1-3(GlcNAcb1-4)[Neu5Aca2-3Galb1-4GlcNAcb1-6)Neu5Aca2-3Galb1-4GlcNacb1-2)Mana1-6]Manb1-4GlcNAcb1-4GlcNAcb-sp 3'A4B-sp *
N-Glycan Neu5Aca2-6Galb1-4GlcNAcb1-2Mana1-3(GlcNAcb1-4)(Neu5Aca2-6Galb1-4GlcNAcb1-2Mana1-6)Manb1-4GlcNAcb1-4GlcNAcb-sp 6'A2B-sp *
N-Glycan Neu5Aca2-6Galb1-4GlcNAcb1-4(Neu5Aca2-6Galb1-4GlcNAcb1-2)Mana1-3(GlcNAcb1-4)(Neu5Aca2-6Galb1-4GlcNAcb1-2Mana1-6)Manb1-4GlcNAcb1-4GlcNAcb-sp 6'A3B(1-4)-sp *
N-Glycan Neu5Aca2-6Galb1-4GlcNAcb1-2Mana1-3(GlcNAcb1-4)(Neu5Aca2-6Galb1-4GlcNAcb1-6[Neu5Aca2-6Galb1-4GlcNAcb1-2)Mana1-6]Manb1-4GlcNAcb1-4GlcNAcb-sp 6'A3B(1-6)-sp *
N-Glycan Neu5Aca2-6Galb1-4GlcNAcb1-4(Neu5Aca2-6Galb1-4GlcNAcb1-2)Mana1-3(GlcNAcb1-4)[Neu5Aca2-6Galb1-4GlcNAcb1-6)Neu5Aca2-6Galb1-4GlcNacb1-2)Mana1-6]Manb1-4GlcNAcb1-4GlcNAcb-sp 6'A4B-sp *
N-Glycan Neu5Aca2-3Galb1-3GlcNAcb1-2Mana1-3(Neu5Aca2-3Galb1-3GlcNAcb1-2)Neu5Aca2-3Galb1-3GlcNAcb1-6)Mana1-6)Manb1-4GlcNAcb1-4GlcNAcb-NK Tri-sLec(b1-6) *
N-Glycan Neu5Aca2-6Galb1-4GlcNAcb1-2Mana1-3(Neu5Aca2-6Galb1-4GlcNAcb1-2)Neu5Aca2-6Galb1-4GlcNAcb1-6)Mana1-6)Manb1-4GlcNAcb1-4GlcNAcb-NK Tri-6'SLN(b-16) *
N-Glycan Neu5Aca2-6Galb1-4GlcNAcb1-2(Neu5Aca2-6Galb1-4GlcNAcb1-6)Mana1-3)(Neu5Aca2-6Galb1-4GlcNAcb1-2)Neu5Aca2-6Galb1-4GlcNAcb1-2)Mana1-6)Manb1-4GlcNAcb1-4GlcNAcb-N Tetra-6'SLN *
O-Glycan Fuca1-2Galb1-4GlcNAcb1-3Galb1-3GalNAca1-Thr Htype-core 1 (HMMC-1 antigen)
O-Glycan Fuca1-2Galb1-4GlcNAcb1-6GalNAca-Thr H-type2 Core 6 X *
O-Glycan Galb1-4GlcNAcb1-3Galb1-3GalNAca1-Thr LN-core1 X
O-Glycan Galb1-4GlcNAcb1-6(Galb1-4GlcNAcb1-3)GalNAca-Thr (Galb4)2 Core 4 X *
O-Glycan Galb1-4GlcNAcb1-6GalNAca-Thr Galb4 Core 6 X *
O-Glycan Neu5Aca2-3(Fuca1-2)Galb1-4GlcNAcb1-6GalNAca-Thr 3'SiaH-type2 Core 6 X *
O-Glycan Neu5Aca2-6(Fuca1-2)Galb1-4GlcNAcb1-6GalNAca-Thr 6'Sia H-type2 Core 6 X *
O-Glycan Neu5Aca2-3Galb1-4GlcNAcb1-6GalNAca-Thr 3'SiaLN- Core 6 X *
O-Glycan Neu5Aca2-6Galb1-4GlcNAcb1-6GalNAca-Thr 6'SiaLN Core 6 X *
Sulfated 3Su-Galb1-3(Fuca1-4)GlcNAcb-sp 3'SuLea X *
Sulfated Neu5Aca2-6(3Su-)Galb1-3GlcNAcb-sp 3'Su6'S Type1 X *
Sulfated Neu5Aca2-6(3Su-)Galb1-3(Fuca1-4)GlcNAcb-sp 3'Su6'SLea X *
Sulfated (6Su-)Galb1-3(Fuca1-4)GlcNAcb-sp 6'SuLea X *
Sulfated Neu5Aca2-3(6Su-)Galb1-3GlcNAcb-sp 6'Su3'SType 1 X *
Sulfated Neu5Aca2-3(6Su-)Galb1-3(Fuca1-4)GlcNAcb-sp 6'Su3'SLea X *
Sulfated Fuca1-2(6Su-)Galb1-3GlcNAcb-sp 6'Su H type 1 X *
Sulfated Fuca1-2(6Su-)Galb1-3(Fuca1-4)GlcNAcb-sp 6'Su Leb X *
Sulfated Neu5Ac2-3[6Su-]Galb1-3[6Su-]GlcNAcb-sp 6,6'di Su 3'S type 1 X *
other Disialyl, monofucosyllacto-N-hexaose-sp DSMFLNH X *
other Monosialyl, monofucosyllacto-N-neohexaose -sp MSMFLnNH X *
other Monosialyllacto-N-hexaose-sp MSLNH X *
other Monosialyl, monofucosyllacto-N-hexaose I-sp MSMFLNH-I X *

PI Inputs/Suggestions

Compounds for the next version of the Mammalian Glycan Array

Compounds for the next version of the Pathogen Glycan Array

Glycans obtained for the Pathogen Array

Antibodies to be screened on the Mammalian Glycan Array

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Last Updated Saturday, 23-Aug-2008 01:21:42 EDT. Please contact us with comments/questions.