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Antibodies to be screened on the Mammalian Glycan Array

The discovery that the CFG printed mammalian glycan array can be used to define the specificity of glycan-specific antibodies in human sera, has opened up a possibility to evaluate the potential of glycan-specific antibodies as biomarkers for cancer. To this end, the CFG plans to assess the specificity of commercial and non-commercial glycan-specific monoclonal antibodies to define their cross-reactivity with other epitopes. The glycan-specific antibodies from commercial and non-commercial antibody resources to be tested on the CFG mammalian glycan array are listed below. The data on the specificities of such antibodies will be posted to the CFG databases, with a view to aid investigators in the development of biomarkers for cancer. Data for antibodies that have been screened can be found at the Primary screen Data page. The table below is sorted by 'Source.'

Antibody Epitope Name Epitope Structure Species/Isotype Source
0.BG.7 Blood Group Kell Antigen IgG AbCam
0.BG.12 Blood Group Tn IgG AbCam
9A Blood Group A IgG AbCam
BRIC231 Blood Group H2 IgG AbCam
Z5H-2/Z2A Blood Group AB IgG AbCam
B35.1 (Anti-Tn antigen, Sialylated mouse mAb) Sialyl Tn antigen GlcNAca 1-Ser/Thr Mouse / IgG1 CalBiochem
NUH2     IgM Clausen, H.
IB3       Clausen, H.
JG1.1.20 PNAD(Addressin)   Rat / IgG2c DSHB
Jones Neural retinal ganglioside Neu5Ac9Ac(a2-8)Neu5Ac(a2-3)Gal(b1-4)Glc(b1-1) Cer Neu5Ac(a2-3)Gal(b1-3)GalNAc(b1-4)[Neu5Ac9Ac(a2-8)Neu5Ac(a2-8)Neu5Ac(a2-3)]Gal(b1-4)Glc(b1-1)Cer Mouse / IgM DSHB
MC631 SSEA-3 (R)-GalNAc(b1-3)Gal(a1-4)Gal-R Rat / IgM DSHB
MC813-70 SSEA-4 Neu5Ac(a2-3)Gal(b1-3)GalNAc(b1-3)Gal(a1-)---R Mouse / IgG3.k DSHB
VIN-2PB-22 GD2 Neu5Ac(a 2-8)Neu5Ac(a 2-3)[GalNAc(b1-4)]Gal(b1-4)Glc(b1-1)Cer Mouse / IgM DSHB
VIN-IS-56 GD2 Neu5Ac(a2-8)Neu5Ac(a2-3)[GalNAc(b1-4)]Gal(b1-4)Glc(b1-1)Cer Mouse / IgM DSHB
GalNac GD1a IgM Seikagaku
GD1a IgM Seikagaku
GD1ba IgG Seikagaku
GD2 IgM Seikagaku
GM1 IgM Seikagaku
GM3 IgM Seikagaku
GQ1b IgM Seikagaku
GT1a IgM Seikagaku
GT1b IgM Seikagaku
Human GD2 IgG Seikagaku
Human GD3 IgM Seikagaku
N-AC-GM2 IgM Seikagaku
N-Glycolyl GM2 IgM Seikagaku
O-Ac-GD3 IgM Seikagaku
GD3 IgM Seikagaku
Human CA19-9 IgG USBio
Human GD1a IgM USBio
Human GD1b IgG USBio
Human GD2 IgG USBio

PI Inputs/Suggestions

Compounds for the next version of the Mammalian Glycan Array

Compounds for the next version of the Pathogen Glycan Array

Glycans obtained for the Pathogen Array

Compounds scheduled for synthesis

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Last Updated Saturday, 23-Aug-2008 01:19:30 EDT. Please contact us with comments/questions.