The NAS report on the glycosciences is now published. The committee makes recommendations in order to achieve a more complete understanding of glycoscience and to realize its impacts on
health, energy, and materials science. Each recommendation is followed by a series of roadmap goals.
On September 1, 2011, the CFG began its official transition to new funding, as the NIGMS 'glue grant' that has supported the CFG since 2001 is ending. As a result, several of the CFG's Scientific Cores are closing, and the CFG website is undergoing a redesign to highlight the resources that will continue to be available. For more information about the transition,
visit the 'About Us' tab at left, and see the September issue of The Consortium Quarterly newsletter.
The CFG has teamed up with the company OpenHelix to create an online tutorial for the Consortium's website, the CFG Functional Glycomics Gateway. The tutorial is designed to help new users navigate the website and help experienced users get the most out of the CFG's extensive data collections, Molecule Pages, analytical tools and resources.
The goal of the Consortium for Functional Glycomics is to define paradigms by which protein-carbohydrate interactions mediate cell communication. Our progress against this goal can now be tracked using the community-built Paradigm Pages.
Thirty exemplary 'paradigm' GBPs have been selected that together cover the scope of biological functions mediated by 9 GBP families studied by the CFG. The wiki-based Paradigm Pages allow CFG investigators to upload and edit detailed information about our progress in understanding these paradigms, with a specific focus on how CFG resources have contributed to progress. The Paradigm Pages, which are open for viewing by the public, offer an in-depth look at a representative range of GBPs from mammalian and microbial sources, and provide a powerful tool for tracking our advances in the final year of glue grant funding and beyond.
INVESTIGATORS UPLOADING DATA
A major goal of the CFG in the final year of glue grant funding is to capture all data resulting from the use of CFG resources in the databases for the lasting benefit of the scientific community. Investigators are actively uploading data related to their open CFG resource requests and closing out completed requests, and are now receiving monthly email reminders to complete this critical task. The chart at right shows the current monthly progress in the data uploading effort. In red are the number of open CFG resource requests which have not yet had data or publications uploaded. In green are the number of requests that have had data/publications uploaded and/or have been closed.
From 2001-2009, Core F generated 26 knockout and conditional knockout mouse lines deficient in glycan-binding proteins or glycosyltransferases. Each of these glycogene targets were specifically chosen by the CFG Mouse Committee and approved by the Steering Committee for their impact on the CFG's overall goal. However, due to overlap with the NIH's Knockout Mouse Project (KOMP), production of novel mouse strains by the CFG was discontinued as of November 1, 2009 by NIGMS mandate.
All existing knockout mouse lines created by Core F have now been transferred to and can be requested from the Mutant Mouse Regional Resource Center (MMRRC) at the University of California, Davis. Some additional Core F targets are also available at the DNA construct, chimera, or embryonic stem cell stage for investigators who wish to complete them in their own labs. For more information on where to find Core F-generated mouse lines, other glycogene knockout lines, and related reagents, visit the
Core F resource page.
This page hosts a tabular Mouse Resource Locator that lists available strains and other reagents, with links to commercial sources and investigators willing to provide living breeding pairs. If you maintain mouse strains of interest to the glycomics community that you would be willing to provide to other investigators, please contact Anna Crie to update the Mouse Resource Locator with your information.
With more than 250 participants, the response was overwhelming. CFG received extremely valuable feedback and suggestions that have helped guide the direction of the CFG over the past year. To view the full results of the survey,
please click here.
'ASSOCIATED REQUESTS/DATA' LINK ADDED TO PARTICIPATING INVESTIGATORS PAGE
The Participating Investigator page has been enhanced by the addition of an 'Associated Requests/Data' link next to each investigator's name. Clicking this link displays that investigator's resource requests, plus any gene microarray or glycan array data posted in the database resulting from those requests.