Request ID: cfg_rRequest_1416
Status
:
Approved
Project Description
:
To characterize the fine specificity of each lectin (BclA, BclB, BclC and BclD) for complex glycans in order to identify the host target of B. cenocepacia and design glycomimics that could compete with the bacteria as anti-adhesive compounds
CFG Member
:
Member
Requester First Name
:
Anne
Requester Last Name
:
Imberty
Head of Lab First Name
:
Anne
Head of Lab Last Name
:
Imberty
Assigned First Name
:
Anne
Assigned Last Name
:
Imberty
Requester Email
:
imberty
Requester Interest
:
This laboratory focuses on structural and thermodynamical characterization of lectin-carbohydrate interactions.
Request Date [yyyy-mm-dd]
:
2008-06-15
Institution
:
CERMAV-CNRS
Shipping Address
:
Information not entered/not applicable.
Comments
:
Information not entered/not applicable.
CFG Core
:
H
Resource Type
:
Glycoarray
Amount Requested
:
Information not entered/not applicable.
Date that your RNA/GBP samples will be sent to the core [yyyy-mm-dd]
:
2026-06-18
Experiment to be conducted
:
To refine the data on Burkholderia cenocepacia lectins obtain in the framework of request 1385. The four different lectins display different patterns, however, due to their high affinity, the data at lower concentration would me much interesting for testing the fine specificity. Concentration of 10 and 50 microgram/ml would be appropriate.
Within Scope of Consortium
:
Y
If yes, indicate the person responsible for inputing data into core B
:
David Smith
GBP being Addressed
:
Lectins labeled with Alexa Fluor and already in Core H facility
Specifc aims being addressed
:
Define the specificity and affinity for carbohydrate ligands. Identify the ligand(s) that mediate GBP binding. Determine the structures of selected GBPs.