Request ID: cfg_rRequest_1797
Status
:
Approved
Project Description
:
Continued studies of RR#1511, RR#1611, and RR#1671 - to develop a binding profile for these additional hemagglutinin (HA) proteins derived from different serotypes of avian influenza A viruses.
CFG Member
:
Member
Requester First Name
:
Xander
Requester Last Name
:
de Haan
Head of Lab First Name
:
Peter
Head of Lab Last Name
:
Rottier
Assigned First Name
:
Peter P.J.M
Assigned Last Name
:
Rottier
Requester Email
:
c.a.m.dehaan@uu.nl
Requester Interest
:
This laboratory is focusing on virus-host interactions at the cellular and molecular level, with particular focus on influenza- and nidoviruses.
Request Date [yyyy-mm-dd]
:
2009-09-22
Institution
:
Virology Division, Utrecht University
Shipping Address
:
Yalelaan 1
3584 CL Utrecht
The Netherlands
Comments
:
Information not entered/not applicable.
CFG Core
:
H
Resource Type
:
Glycoarray
Amount Requested
:
Information not entered/not applicable.
Date that your RNA/GBP samples will be sent to the core [yyyy-mm-dd]
:
2025-02-13
Experiment to be conducted
:
Previously we have defined the experimental conditions to analayze influenza A virus HA-carbohydrate interactions using glycoarrays. We were able to distinguish specific binding specificities for HA2 and HA7 derived from avian viruses. We would now like to extent this analysis by studying the binding profile of different HAs (from serotypes)derived from avian influenza A viruses.
Within Scope of Consortium
:
Y
If yes, indicate the person responsible for inputing data into core B
:
Xander de Haan
GBP being Addressed
:
The purified proteins (7 in total) will be sent together with the primary antibody. The same protocol as used in requests 1611/1671 will be used.
Specifc aims being addressed
:
Define the specificity and affinity for carbohydrate ligands.