Request ID: cfg_rRequest_977
Status
:
Approved
Project Description
:
To study the fine specificity of each galectin for high affinity ligands
CFG Member
:
Galectin
Requester First Name
:
Richard
Requester Last Name
:
Cummings
Head of Lab First Name
:
Richard
Head of Lab Last Name
:
Cummings
Assigned First Name
:
Richard D.
Assigned Last Name
:
Cummings
Requester Email
:
rdcummi@emory.edu
Requester Interest
:
The Cummings' group studies the structure and biosynthesis of glycan-based ligands for carbohydrate-binding proteins (selectins and galectins) and the biological functions of protein-carbohydrate interactions in regulating cell adhesion, signaling, and cell turnover in a variety of systems, including humans, animals, C. elegans and parasitic worms. This laboratory also studies the specific cellular and humoral immune responses to glycan antigens expressed by parasites in infected animals.
Request Date [yyyy-mm-dd]
:
2007-03-20
Institution
:
Emory
Shipping Address
:
Information not entered/not applicable.
Comments
:
Information not entered/not applicable.
CFG Core
:
H
Resource Type
:
Glycoarray
Amount Requested
:
Information not entered/not applicable.
Date that your RNA/GBP samples will be sent to the core [yyyy-mm-dd]
:
2025-03-25
Experiment to be conducted
:
Our dose response screening with human Galectin-7 provided key insight into the fine specificity of this galectin (at nM concentrations it only bound H antigen, providing the most specific interaction reported for any galectin to date). We would now like to examine other galectins using this same format and believe that this will provide significant insight into the fine specificity of each galectin for high affinity ligands. We currently request 20-25 slides for this analysis.
Within Scope of Consortium
:
Y
If yes, indicate the person responsible for inputing data into core B
:
Dr. Dave Smith
GBP being Addressed
:
galectins
Specifc aims being addressed
:
Define the specificity and affinity for carbohydrate ligands.