Request ID: cfg_rRequest_979
Status
:
Approved
Project Description
:
To determine the fine specificity of P-Selectin-Ig chimera (mouse and human), L-Selectin-Ig chimera (mouse and human), E-Selectin-Ig Chimera (mouse and human).
CFG Member
:
C-type lectin
Requester First Name
:
Jamie
Requester Last Name
:
Heimburg
Head of Lab First Name
:
Richard
Head of Lab Last Name
:
Cummings
Assigned First Name
:
Richard D.
Assigned Last Name
:
Cummings
Requester Email
:
jheimbu@emory.edu
Requester Interest
:
The Cummings' group studies the structure and biosynthesis of glycan-based ligands for carbohydrate-binding proteins (selectins and galectins) and the biological functions of protein-carbohydrate interactions in regulating cell adhesion, signaling, and cell turnover in a variety of systems, including humans, animals, C. elegans and parasitic worms. This laboratory also studies the specific cellular and humoral immune responses to glycan antigens expressed by parasites in infected animals.
Request Date [yyyy-mm-dd]
:
2007-03-20
Institution
:
Emory University
Shipping Address
:
Information not entered/not applicable.
Comments
:
Information not entered/not applicable.
CFG Core
:
H
Resource Type
:
Information not entered/not applicable.
Amount Requested
:
Information not entered/not applicable.
Date that your RNA/GBP samples will be sent to the core [yyyy-mm-dd]
:
0007-03-26
Experiment to be conducted
:
We would like to test the specificity of the selectins for ligands by screening on the glycan array.
Within Scope of Consortium
:
Y
If yes, indicate the person responsible for inputing data into core B
:
David Smith
GBP being Addressed
:
P-Selectin-Ig chimera (mouse and human), L-Selectin-Ig chimera (mouse and human), E-selectin-Ig chimera (mouse and human)
Specifc aims being addressed
:
Define the specificity and affinity for carbohydrate ligands. Identify the ligand(s) that mediate GBP binding. Determine the structures of selected GBPs.