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DcSign (Cd209a)

Dendritic cell-specific ICAM-3 (intercellular adhesion molecule-3) g rabbing non-integrin is a type II membrane protein with an external mannose-binding, C-type lectin domain. Based on the genomic structure and the predicted functional domains of the protein, a non-conditional targeted vector was designed deleting exons 1 to 5 (inclusive) and replacing them with a selectable marker.