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Langerin, a C-type lectin, plays a role in antigen processing and presentation. It is a potent inducer of Birbeck granule formation in Langerhans cells and is involved in nonconventional endocytic receptor routing into these organelles. Based on the genomic structure and the predicted functional domains, a non-conditional targeting strategy was designed where exons 1 to 4 are replaced by a floxed selectable marker.