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SiglecH belongs to a superfamily of cell surface proteins able to recognize sialic acids via a binding site in the N-terminal V-set Ig-like domain and sharing structural motifs in the first two C2-set Ig-like domains (hence the name Siglecs: sialic acid-binding immunoglobulin-like lectins). Very little is known about the function and expression pattern of this particular member of the family although the DNA sequence was determined from the full length cDNA clone.

Based on the genomic structure and the predicted functional domains, a targeting vector was designed where the first two exons were floxed by cre-recombinase recognition sites, removing the majority of the coding sequences including both Ig-like domains and alternatively spliced exon 2a.